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Department of Surgery, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, New Jersey 08084
The objectives of this study were to assess oxidant
damage during and after spaceflight and to compare the results against bed rest with 6° head-down tilt. We measured the urinary excretion of the F2 isoprostane, 8-iso-prostaglandin (PG)
F2
, and 8-oxo-7,8-dihydro-2 deoxyguanosine (8-OH DG)
before, during, and after long-duration spaceflight (4-9 mo) on
the Russian space station MIR, short-duration spaceflight on the
shuttle, and 17 days of bed rest. Sample collections on MIR were
obtained between 88 and 186 days in orbit. 8-iso-PGF2 and 8-OH DG are markers for oxidative damage to membrane lipids and
DNA, respectively. Data are mean ± SE. On MIR, isoprostane levels
were decreased inflight (96.9 ± 11.6 vs. 76.7 ± 14.9 ng · kg
1 · day1,
P < 0.05, n = 6) due to decreased dietary intake
secondary to impaired thermoregulation. Isoprostane excretion was
increased postflight (245.7 ± 55.8 ng · kg1 · day1,
P < 0.01). 8-OH DG excretion was unchanged with spaceflight and increased postflight (269 ± 84 vs 442 ± 180 ng · kg1 · day1,
P < 0.05). On the shuttle, 8-OH DG excretion was
unchanged in- and postflight, but 8-iso-PGF2 excretion
was decreased inflight (15.6 ± 4.3 vs 8.0 ± 2.7 ng · kg1 · day1,
P < 0.05). No changes were found with bed rest, but
8-iso-PGF2 was increased during the recovery phase (48.9 ± 23.0 vs 65.4 ± 28.3 ng · kg1 · day1,
P < 0.05). The changes in isoprostane production were
attributed to decreased production of oxygen radicals from the electron
transport chain due to the reduced energy intake inflight. The
postflight increases in the excretion of the products of oxidative
damage were attributed to a combination of an increase in metabolic
activity and the loss of some host antioxidant defenses inflight. We
conclude that 1) oxidative damage was decreased inflight, and
2) oxidative damage was increased postflight.
isoprostanes; 8-hydroxydeoxyguanosine
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