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Am J Physiol Endocrinol Metab 278: E302-E307, 2000;
0193-1849/00 $5.00
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Vol. 278, Issue 2, E302-E307, February 2000

Effects of thyroid hormone on action potential and repolarizing currents in rat ventricular myocytes

Zhuo-Qian Sun1,2, Kaie Ojamaa2, William A. Coetzee1, Michael Artman1, and Irwin Klein2

1 Pediatric Cardiology, New York University Medical Center, New York 10016; 2 Division of Endocrinology, Department of Medicine, North Shore University Hospital/New York University School of Medicine, Manhasset, New York 11030

Thyroid hormones play an important role in cardiac electrophysiology through both genomic and nongenomic mechanisms of action. The effects of triiodothyronine (T3) on the electrophysiological properties of ventricular myocytes isolated from euthyroid and hypothyroid rats were studied using whole cell patch clamp techniques. Hypothyroid ventricular myocytes showed significantly prolonged action potential duration (APD90) compared with euthyroid myocytes, APD90 of 151 ± 5 vs. 51 ± 8 ms, respectively. Treatment of hypothyroid ventricular myocytes with T3 (0.1 µM) for 5 min significantly shortened APD by 24% to 115 ± 10 ms. T3 similarly shortened APD in euthyroid ventricular myocytes, but only in the presence of 4-aminopyridine (4-AP), an inhibitor of the transient outward current (Ito), which prolonged the APD by threefold. Transient outward current (Ito) was not affected by the acute application of T3 to either euthyroid or hypothyroid myocytes; however, Ito density was significantly reduced in hypothyroid compared with euthyroid ventricular myocytes.

acute effects of triiodothyronine; heart; transient outward current; delayed rectifier current


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