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Am J Physiol Endocrinol Metab 278: E273-E279, 2000;
0193-1849/00 $5.00
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Vol. 278, Issue 2, E273-E279, February 2000

Combined effects of hyperaminoacidemia and oxandrolone on skeletal muscle protein synthesis

Melinda Sheffield-Moore1, Robert R. Wolfe1,2,4, Dennis C. Gore1, Steven E. Wolf1, Dennis M. Ferrer3, and Arny A. Ferrando1

Departments of 1 Surgery, 2 Anesthesiology, and 3 Internal Medicine, University of Texas Medical Branch, and 4 Shriners Burns Hospital for Children, Galveston, Texas 77550

We investigated whether the normal anabolic effects of acute hyperaminoacidemia were maintained after 5 days of oxandrolone (Oxandrin, Ox)-induced anabolism. Five healthy men [22 ± 3 (SD) yr] were studied before and after 5 days of oral Ox (15 mg/day). In each study, a 5-h basal period was followed by a 3-h primed-continuous infusion of a commercial amino acid mixture (10% Travasol). Stable isotopic data from blood and muscle sampling were analyzed using a three-compartment model to calculate muscle protein synthesis and breakdown. Model-derived muscle protein synthesis increased after amino acid infusion in both the control [basal control (BC) vs. control + amino acids (C+AA); P < 0.001] and Ox study [basal Ox (BOx) vs. Ox + amino acids (Ox+AA); P < 0.01], whereas protein breakdown was unchanged. Fractional synthetic rates of muscle protein increased 94% (BC vs. C+AA; P = 0.01) and 53% (BOx vs. Ox+AA; P < 0.01), respectively. We conclude that the normal anabolic effects of acute hyperaminoacidemia are maintained in skeletal muscle undergoing oxandrolone-induced anabolism.

anabolic agent; amino acids; stable isotopes


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