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Am J Physiol Endocrinol Metab 278: E153-E161, 2000;
0193-1849/00 $5.00
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Vol. 278, Issue 1, E153-E161, January 2000

Effect of weight reduction, obesity predisposition, and aerobic fitness on skeletal muscle mitochondrial function

D. Enette Larson-Meyer1, Bradley R. Newcomer2, Gary R. Hunter3, James E. McLean3, Hoby P. Hetherington4, and Roland L. Weinsier1

1 Division of Physiology and Metabolism, Department of Nutrition Sciences, 2 Department of Critical and Diagnostic Care, and 3 Department of Human Studies, The University of Alabama at Birmingham, Birmingham, Alabama 35294; and 4 Medical Department, Brookhaven National Laboratory, Upton, New York 11973

We used 31P magnetic resonance spectroscopy to measure maximal mitochondrial function in 12 obesity-prone women before and after diet-induced weight reduction and in 12 matched, never-obese, and 7 endurance-trained controls. Mitochondrial function was modeled after maximum-effort plantar flexion from the phosphocreatine recovery time constant (TCPCr), the ADP recovery time constant (TCADP), and the rate of change in PCr during the first 14 s of recovery (OxPhos). Weight reduction was not associated with a significant change in mitochondrial function by TCPCr, TCADP, or OxPhos. Mitochondrial function was not different between postobese and never-obese controls by TCPCr [35.1 ± 2.5 (SE) vs. 34.6 ± 2.5 s], TCADP (22.9 ± 1.8 vs. 21.2 ± 1.8 s), or OxPhos (0.26 ± 0.03 vs. 0.25 ± 0.03 mM ATP/s), postobese vs. never-obese, respectively. However, TCADP was significantly faster (14.5 ± 2.3 s), and OxPhos was significantly higher (0.38 ± 0.04 mM ATP/s) in the endurance-trained group. These results suggest that maximal mitochondrial function is not impaired in normal-weight obesity-prone women relative to their never-obese counterparts but is increased in endurance-trained women.

nuclear magnetic resonance; skeletal muscle; oxidative phosphorylation; endurance training


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