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Am J Physiol Endocrinol Metab 277: E971-E975, 1999;
0193-1849/99 $5.00
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Vol. 277, Issue 6, E971-E975, December 1999

Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo

Vidya Mohamed-Ali1, Steven Goodrick1, Karen Bulmer1, Jeffrey M. P. Holly2, John S. Yudkin1, and Simon W. Coppack1

1 Centre for Diabetes and Cardiovascular Risk, University College London Medical School, London N19 3UA; and 2 Division of Surgery, University Department of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom

To investigate in vivo adipose tissue production of tumor necrosis factor-alpha (TNF-alpha ), interleukin-6 (IL-6), and their soluble receptors: TNF receptor type I (sTNFR-I), TNF receptor type II (sTNFR-II), and IL-6 receptor (sIL-6R), we determined arteriovenous differences in their levels across abdominal subcutaneous adipose tissue in obese subjects. Subjects had a median (interquartile range) age of 44.5 (27-51.3) yr, body mass index (BMI) of 32.9 (26.0-46.6) kg/m2, and %body fat of 42.5 (28.5-51.2) %. Although there was not a significant difference in the arteriovenous concentrations of TNF-alpha (P = 0.073) or sTNFR-II (P = 0.18), the levels of sTNFR-I (P = 0.002) were higher in the vein compared with artery, suggesting adipose tissue production of this soluble receptor. There was a significant arteriovenous difference in IL-6 (P < 0.001) but not in its soluble receptor (P = 0.18). There was no relationship between TNF-alpha levels and adiposity indexes (rs = 0.12-0.22, P = not significant); however, levels of both its soluble receptor isomers correlated significantly with BMI and %body fat (sTNFR-I rs = 0.42-0.72, P < 0.001; sTNFR-II rs = 0.36-0.65, P < 0.05- <0.001). IL-6 levels correlated significantly with both BMI and %body fat (rs = 0.51, P = 0.004, and rs = 0.63, P < 0.001), but sIL-6R did not. In conclusion, 1) soluble TNFR-I is produced by adipose tissue, and concentrations of both soluble isoforms correlate with the degree of adiposity, and 2) IL-6, but not its soluble receptor, is produced by adipose tissue and relates to adiposity.

interleukin-6; tumor necrosis factor-alpha ; soluble receptors; obesity


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