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Am J Physiol Endocrinol Metab 277: E1103-E1110, 1999;
0193-1849/99 $5.00
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Vol. 277, Issue 6, E1103-E1110, December 1999

Contraction-stimulated muscle glucose transport and GLUT-4 surface content are dependent on glycogen content

Wim Derave1,2, Sten Lund3, Geoffrey D. Holman4, Jørgen Wojtaszewski1, Oluf Pedersen5, and Erik A. Richter1

1 Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, 2100 Copenhagen; 5 Steno Diabetes Center and Hagedorn Research Institute, 2820 Gentofte, Copenhagen; 3 Medical Research Laboratory, Aarhus Kommunehospital, 8000 Aarhus, Denmark; 2 Department of Movement and Sports Sciences, University of Gent, 9000 Gent, Belgium; and 4 Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom

The influence of muscle glycogen content on basal and contraction-induced glucose transport and cell surface GLUT-4 content was studied in rat skeletal muscle. Wistar rats were preconditioned by a combination of swimming exercise and diet, resulting in 40% lower (LG) or threefold higher (HG) muscle glycogen content compared with nonexercised controls (NG). At rest and during contractions, 2-deoxy-D-glucose uptake in perfused fast-twitch muscle, but not slow-twitch muscle, was significantly lower in HG compared with LG. Cell surface GLUT-4 content in the fast-twitch plantaris was 994 ± 180, 1,173 ± 311, and 2,155 ± 243 dpm/g in the basal condition and increased (P < 0.05) to 2,285 ± 239, 3,230 ± 464, and 4,847 ± 654 dpm/g during contractions with HG, NG, and LG, respectively, the increase being significantly smaller in HG compared with LG. The contraction-induced increments in glucose transport and in cell surface GLUT-4 content were negatively correlated with the initial glycogen content (P <0.01). In conclusion, glucose transport and cell surface GLUT-4 content in resting and contracting fast-twitch muscle are dependent on the muscle glycogen content.

glucose transporters; exercise; glycogen metabolism; perfused hindlimb; 2-deoxy-D-glucose


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