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Human Performance Laboratory and Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858
The purpose of this study was to determine if
the improvement in insulin sensitivity with exercise training is
associated with enhanced phosphatidylinositol 3-kinase (PI 3-kinase)
activity. Nine sedentary men were studied before and after 7 days of
exercise training (1 h/day, 
75% maximal oxygen consumption).
Insulin sensitivity was determined with a euglycemic-hyperinsulinemic
glucose clamp in the sedentary state and 15-17 h after the final
exercise bout. PI 3-kinase activity was determined from samples (vastus
lateralis) obtained in the fasted condition and after 60 min of
submaximal insulin stimulation during the clamp. After exercise,
glucose infusion rate increased (P < 0.05) significantly (means ± SE, 7.8 ± 0.5 vs. 9.8 ± 0.8 mg · kg
1 · min1),
indicating improved insulin sensitivity. Insulin-stimulated (insulin
stimulated/fasting) phosphotyrosine immunoprecipitable PI 3-kinase
activity also increased significantly
(P < 0.05) with exercise (3.1 ± 0.8-fold) compared with the sedentary condition (1.3 ± 0.1-fold).
There was no change in fasting PI 3-kinase activity. These data suggest
that an enhancement of insulin signal transduction in skeletal muscle
may contribute to the improvement in insulin action with exercise.
insulin signaling; contractile activity; striated muscle; physical activity, phosphatidylinositol 3-kinase
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