AJP - Endo Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 277: E585-E590, 1999;
0193-1849/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takala, T. O.
Right arrow Articles by Knuuti, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takala, T. O.
Right arrow Articles by Knuuti, J.
Vol. 277, Issue 4, E585-E590, October 1999

Myocardial blood flow, oxygen consumption, and fatty acid uptake in endurance athletes during insulin stimulation

Teemu O. Takala1,2, Pirjo Nuutila1, Chietsugu Katoh2,3, Matti Luotolahti4, Jörgen Bergman2, Maija Mäki2, Vesa Oikonen2, Ulla Ruotsalainen2, Tove Grönroos2, Merja Haaparanta2, Jukka Kapanen5, and Juhani Knuuti2

Departments of 1 Medicine and 4 Clinical Physiology, 2 Turku PET Centre, and 5 Sports and Exercise Medicine Unit, Paavo Nurmi Centre, University of Turku, FIN-20521 Turku, Finland; and 3 Department of Nuclear Medicine, Hokkaido University, Sapporo, 060-8638 Japan

We have previously demonstrated reduced myocardial glucose uptake rates in hearts of endurance athletes, which could be due to increased use of alternative fuels or reduced energy demands. In the present study myocardial blood flow, oxygen consumption, and free fatty acid uptake were measured with [15O]H2O, [15O]O2, [18F]FTHA, and positron emission tomography (PET) in 9 endurance athletes and 11 sedentary men during euglycemic hyperinsulinemia. Compared with sedentary men, athletes had 33% lower myocardial blood flow, 27% lower oxygen consumption, and 20% lower estimated myocardial work per gram of tissue. Myocardial fatty acid uptake rates were not significantly different in endurance athletes (0.83 ± 0.29) and sedentary men (1.0 ± 0.31 µmol · 100 g-1 · min-1, P = 0.232). In conclusion, myocardial blood flow and oxygen consumption per unit mass of myocardium are reduced at rest in endurance athletes. This can be explained by reduced energy requirements per gram of tissue due to anatomic and physiological changes of the athlete's heart.

exercise; positron emission tomography; free fatty acid; myocardial metabolism; skeletal muscle


This article has been cited by other articles:


Home page
 J. Physiol.Home page
J. C. Hannukainen, P. Nuutila, B. Ronald, J. Kaprio, U. M. Kujala, T. Janatuinen, O. J. Heinonen, J. Kapanen, T. Viljanen, M. Haaparanta, et al.
Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins
J. Physiol., January 1, 2007; 578(1): 347 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Indermuhle, R. Vogel, P. Meier, S. Wirth, R. Stoop, M. G. Mohaupt, and C. Seiler
The relative myocardial blood volume differentiates between hypertensive heart disease and athlete's heart in humans
Eur. Heart J., July 1, 2006; 27(13): 1571 - 1578.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online