AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 277: E342-E351, 1999;
0193-1849/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chatham, J. C.
Right arrow Articles by Forder, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chatham, J. C.
Right arrow Articles by Forder, J. R.
Vol. 277, Issue 2, E342-E351, August 1999

Impact of 1 wk of diabetes on the regulation of myocardial carbohydrate and fatty acid oxidation

John C. Chatham, Zhi-Ping Gao, and John R. Forder

Division of Nuclear Magnetic Resonance Research, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

The aim of this study was to investigate the effect of increasing exogenous palmitate concentration on carbohydrate and palmitate oxidation in hearts from control and 1-wk diabetic rats. Hearts were perfused with glucose, [3-13C]lactate, and [U-13C]palmitate. Substrate oxidation rates were determined by combining 13C-NMR glutamate isotopomer analysis of tissue extracts with measurements of oxygen consumption. Carbohydrate oxidation was markedly depressed after diabetes in the presence of low (0.1 mM) but not high (1.0 mM) palmitate concentration. Increasing exogenous palmitate concentration 10-fold resulted in a 7-fold increase in the contribution of palmitate to energy production in controls but only a 30% increase in the diabetic group. Consequently, at 0.1 mM palmitate, the rate of fatty acid oxidation was higher in the diabetic group than in controls; however, at 1.0 mM fatty acid oxidation, it was significantly depressed. Therefore, after 1 wk of diabetes, the major differences in carbohydrate and fatty acid metabolism occur primarily at low rather than high exogenous palmitate concentration.

palmitate; 13C-nuclear magnetic resonance spectroscopy


This article has been cited by other articles:


Home page
 CirculationHome page
S. Boudina and E. D. Abel
Diabetic Cardiomyopathy Revisited
Circulation, June 26, 2007; 115(25): 3213 - 3223.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Fulop, Z. Zhang, R. B. Marchase, and J. C. Chatham
Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation
Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2227 - H2236.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. D. Thakker, N. G. Frangogiannis, M. Bujak, P. Zymek, J. W. Gaubatz, A. K. Reddy, G. Taffet, L. H. Michael, M. L. Entman, and C. M. Ballantyne
Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2504 - H2514.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. An and B. Rodrigues
Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1489 - H1506.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. O'Donnell, M. Zampino, N. M. Alpert, M. J. Fasano, D. L. Geenen, and E.D. Lewandowski
Accelerated triacylglycerol turnover kinetics in hearts of diabetic rats include evidence for compartmented lipid storage
Am J Physiol Endocrinol Metab, March 1, 2006; 290(3): E448 - E455.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Wang, S. G. Lloyd, H. Zeng, A. Bonen, and J. C. Chatham
Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2102 - H2110.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. G. Lloyd, P. Wang, H. Zeng, and J. C. Chatham
Impact of low-flow ischemia on substrate oxidation and glycolysis in the isolated perfused rat heart
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H351 - H362.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Wang and J. C. Chatham
Onset of diabetes in Zucker diabetic fatty (ZDF) rats leads to improved recovery of function after ischemia in the isolated perfused heart
Am J Physiol Endocrinol Metab, May 1, 2004; 286(5): E725 - E736.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Khairallah, F. Labarthe, B. Bouchard, G. Danialou, B. J. Petrof, and C. Des Rosiers
Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons
Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1461 - H1470.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Lloyd, C. Brocks, and J. C. Chatham
Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart
Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H163 - H172.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. L. Hall, G. H. Gibbons, and J. C. Chatham
IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells
Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E465 - E471.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. C Chatham and A.-M. L Seymour
Cardiac carbohydrate metabolism in Zucker diabetic fatty rats
Cardiovasc Res, July 1, 2002; 55(1): 104 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. C. Chatham, C. Des Rosiers, and J. R. Forder
Evidence of separate pathways for lactate uptake and release by the perfused rat heart
Am J Physiol Endocrinol Metab, October 1, 2001; 281(4): E794 - E802.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. L. Hall, J. C. Chatham, H. Eldar-Finkelman, and G. H. Gibbons
Upregulation of Glucose Metabolism During Intimal Lesion Formation Is Coupled to the Inhibition of Vascular Smooth Muscle Cell Apoptosis: Role of GSK3{beta}
Diabetes, May 1, 2001; 50(5): 1171 - 1179.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. M. King, R. J. Sidell, J. R. Wilding, G. K. Radda, and K. Clarke
Free fatty acids, but not ketone bodies, protect diabetic rat hearts during low-flow ischemia
Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1173 - H1181.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online