AJP - Endo AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 277: E81-E92, 1999;
0193-1849/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bergman, B. C.
Right arrow Articles by Brooks, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bergman, B. C.
Right arrow Articles by Brooks, G. A.
Vol. 277, Issue 1, E81-E92, July 1999

Muscle net glucose uptake and glucose kinetics after endurance training in men

B. C. Bergman1, G. E. Butterfield2, E. E. Wolfel3, G. D. Lopaschuk4, G. A. Casazza1, M. A. Horning1, and G. A. Brooks1

1 Department of Integrative Biology, University of California, Berkeley 94720; 2 Geriatric Research, Education, and Clinical Center, Palo Alto Veterans Affairs Health Care System, Palo Alto, California 95304; 3 Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado 80262; and 4 Cardiovascular Research Group, Departments of Pediatrics and Pharmacology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2

We evaluated the hypotheses that alterations in glucose disposal rate (Rd) due to endurance training are the result of changed net glucose uptake by active muscle and that blood glucose is shunted to working muscle during exercise requiring high relative power output. We studied leg net glucose uptake during 1 h of cycle ergometry at two intensities before training [45 and 65% of peak rate of oxygen consumption (VO2 peak)] and after training [65% pretraining VO2 peak, same absolute workload (ABT), and 65% posttraining VO2 peak, same relative workload (RLT)]. Nine male subjects (178.1 ± 2.5 cm, 81.8 ± 3.3 kg, 27.4 ± 2.0 yr) were tested before and after 9 wk of cycle ergometer training, five times a week at 75% VO2 peak. The power output that elicited 66.0 ± 1.1% of VO2 peak before training elicited 54.0 ± 1.7% after training. Whole body glucose Rd decreased posttraining at ABT (5.45 ± 0.31 mg · kg-1 · min-1 at 65% pretraining to 4.36 ± 0.44 mg · kg-1 · min-1) but not at RLT (5.94 ± 0.47 mg · kg-1 · min-1). Net glucose uptake was attenuated posttraining at ABT (1.87 ± 0.42 mmol/min at 65% pretraining and 0.54 ± 0.33 mmol/min) but not at RLT (2.25 ± 0.81 mmol/min). The decrease in leg net glucose uptake at ABT was of similar magnitude as the drop in glucose Rd and thus could explain dampened glucose flux after training. Glycogen degradation also decreased posttraining at ABT but not RLT. Leg net glucose uptake accounted for 61% of blood glucose flux before training and 81% after training at the same relative (65% VO2 peak) workload and only 38% after training at ABT. We conclude that 1) alterations in active muscle glucose uptake with training determine changes in whole body glucose kinetics; 2) muscle glucose uptake decreases for a given, moderate intensity task after training; and 3) hard exercise (65% VO2 peak) promotes a glucose shunt from inactive tissues to active muscle.

exertion; glycogen; lactate; stable isotopes; crossover concept


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
Z. A. Zarins, M. L. Johnson, N. Faghihnia, M. A. Horning, G. A. Wallis, J. A. Fattor, and G. A. Brooks
Training improves the response in glucose flux to exercise in postmenopausal women
J Appl Physiol, July 1, 2009; 107(1): 90 - 97.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. C. A. Akerstrom, C. P. Fischer, P. Plomgaard, C. Thomsen, G. van Hall, and B. K. Pedersen
Glucose ingestion during endurance training does not alter adaptation
J Appl Physiol, June 1, 2009; 106(6): 1771 - 1779.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. C. Bergman, T. Tsvetkova, B. Lowes, and E. E. Wolfel
Myocardial glucose and lactate metabolism during rest and atrial pacing in humans
J. Physiol., May 1, 2009; 587(9): 2087 - 2099.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. C. Bergman, T. Tsvetkova, B. Lowes, and E. E. Wolfel
Myocardial FFA metabolism during rest and atrial pacing in humans
Am J Physiol Endocrinol Metab, February 1, 2009; 296(2): E358 - E366.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. B. Nielsen, M. A. Febbraio, P. Ott, P. Krustrup, and N. H. Secher
Hepatic lactate uptake versus leg lactate output during exercise in humans
J Appl Physiol, October 1, 2007; 103(4): 1227 - 1233.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. L. Friedlander, K. A. Jacobs, J. A. Fattor, M. A. Horning, T. A. Hagobian, T. A. Bauer, E. E. Wolfel, and G. A. Brooks
Contributions of working muscle to whole body lipid metabolism are altered by exercise intensity and training
Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E107 - E116.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. C. Devries, M. J. Hamadeh, S. M. Phillips, and M. A. Tarnopolsky
Menstrual cycle phase and sex influence muscle glycogen utilization and glucose turnover during moderate-intensity endurance exercise
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R1120 - R1128.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Zhou, J. E. Salem, G. M. Saidel, W. C. Stanley, and M. E. Cabrera
Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2400 - H2411.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. C. Henderson, M. A. Horning, S. L. Lehman, E. E. Wolfel, B. C. Bergman, and G. A. Brooks
Pyruvate shuttling during rest and exercise before and after endurance training in men
J Appl Physiol, July 1, 2004; 97(1): 317 - 325.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S.-H. Suh, G. A. Casazza, M. A. Horning, B. F. Miller, and G. A. Brooks
Effects of oral contraceptives on glucose flux and substrate oxidation rates during rest and exercise
J Appl Physiol, January 1, 2003; 94(1): 285 - 294.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S.-H. Suh, G. A. Casazza, M. A. Horning, B. F. Miller, and G. A. Brooks
Luteal and follicular glucose fluxes during rest and exercise in 3-h postabsorptive women
J Appl Physiol, July 1, 2002; 93(1): 42 - 50.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. K. Trimmer, J.-M. Schwarz, G. A. Casazza, M. A. Horning, N. Rodriguez, and G. A. Brooks
Measurement of gluconeogenesis in exercising men by mass isotopomer distribution analysis
J Appl Physiol, July 1, 2002; 93(1): 233 - 241.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. L. Carter, C. Rennie, and M. A. Tarnopolsky
Substrate utilization during endurance exercise in men and women after endurance training
Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E898 - E907.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. K. Trimmer, G. A. Casazza, M. A. Horning, and G. A. Brooks
Autoregulation of glucose production in men with a glycerol load during rest and exercise
Am J Physiol Endocrinol Metab, April 1, 2001; 280(4): E657 - E668.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Carter, S. McKenzie, M. Mourtzakis, D. J. Mahoney, and M. A. Tarnopolsky
Short-term 17{beta}-estradiol decreases glucose Ra but not whole body metabolism during endurance exercise
J Appl Physiol, January 1, 2001; 90(1): 139 - 146.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Kristiansen, J. Gade, J. F. P. Wojtaszewski, B. Kiens, and E. A. Richter
Glucose uptake is increased in trained vs. untrained muscle during heavy exercise
J Appl Physiol, September 1, 2000; 89(3): 1151 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. Dubouchaud, G. E. Butterfield, E. E. Wolfel, B. C. Bergman, and G. A. Brooks
Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle
Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E571 - E579.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. C. Bergman, M. A. Horning, G. A. Casazza, E. E. Wolfel, G. E. Butterfield, and G. A. Brooks
Endurance training increases gluconeogenesis during rest and exercise in men
Am J Physiol Endocrinol Metab, February 1, 2000; 278(2): E244 - E251.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. C. Bergman, E. E. Wolfel, G. E. Butterfield, G. D. Lopaschuk, G. A. Casazza, M. A. Horning, and G. A. Brooks
Active muscle and whole body lactate kinetics after endurance training in men
J Appl Physiol, November 1, 1999; 87(5): 1684 - 1696.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online