AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 277: E135-E143, 1999;
0193-1849/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Singh, M. A. F.
Right arrow Articles by Evans, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Singh, M. A. F.
Right arrow Articles by Evans, W. J.
Vol. 277, Issue 1, E135-E143, July 1999

Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders

Maria A. Fiatarone Singh1,2,3, Wenjing Ding1,4, Thomas J. Manfredi5, Guido S. Solares1, Evelyn F. O'Neill2, Karen M. Clements2, Nancy D. Ryan2, Joseph J. Kehayias1, Roger A. Fielding1,4, and William J. Evans6

1 Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston 02111; 2 Hebrew Rehabilitation Center for Aged, Boston 02131; 4 Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, Massachusetts 02215; 5 Exercise Science Laboratory, University of Rhode Island, Kingston, Rhode Island 02906; 6 Nutrition, Exercise, and Metabolism Division, Donald W. Reynolds Department of Geriatrics and Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Veterans Affairs Medical Center, Little Rock, Arkansas 72114; and 3 School of Exercise and Sport Science, University of Sydney, Lidcombe, New South Wales 1825, Australia

To assess muscle remodeling and functional adaptation to exercise and diet interventions, 26 men and women aged 72-98 yr underwent a vastus lateralis biopsy before and after placebo control condition, and progressive resistance training, multinutrient supplementation, or both. Type II atrophy, Z band, and myofibril damage were present at baseline. Combined weight lifting and nutritional supplementation increased strength by 257 ± 62% (P = 0.0001) and type II fiber area by 10.1 ± 9.0% (P = 0.033), with a similar trend for type I fiber area (+12.8 ± 22.2%). Exercise was associated with a 2.5-fold increase in neonatal myosin staining (P = 0.0009) and an increase of 491 ± 137% (P < 0.0001) in IGF-I staining. Ultrastructural damage increased by 141 ± 59% after exercise training (P = 0.034). Strength increases were largest in those with the greatest increases in myosin, IGF-I, damage, and caloric intake during the trial. Age-related sarcopenia appears largely confined to type II muscle fibers. Frail elders respond robustly to resistance training with musculoskeletal remodeling, and significant increases in muscle area are possible with resistance training in combination with adequate energy intakes.

sarcopenia; muscle biopsy; resistance training; muscle damage


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. E. Dupont-Versteegden, R. Nagarajan, M. L. Beggs, E. D. Bearden, P. M. Simpson, and C. A. Peterson
Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1263 - R1273.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. P. Lambert, N. R. Wright, B. N. Finck, and D. T. Villareal
Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons
J Appl Physiol, August 1, 2008; 105(2): 473 - 478.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Slivka, U. Raue, C. Hollon, K. Minchev, and S. Trappe
Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R273 - R280.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. D. Hand, M. C. Kostek, R. E. Ferrell, M. J. Delmonico, L. W. Douglass, S. M. Roth, J. M. Hagberg, and B. F. Hurley
Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults
J Appl Physiol, November 1, 2007; 103(5): 1678 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. I. Lewis, M. Fournier, T. W. Storer, S. Bhasin, J. Porszasz, S.-G. Ren, X. Da, and R. Casaburi
Skeletal muscle adaptations to testosterone and resistance training in men with COPD
J Appl Physiol, October 1, 2007; 103(4): 1299 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. D. R. Harridge
Plasticity of human skeletal muscle: gene expression to in vivo function
Exp Physiol, September 1, 2007; 92(5): 783 - 797.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. M. Heinemeier, J. L. Olesen, P. Schjerling, F. Haddad, H. Langberg, K. M. Baldwin, and M. Kjaer
Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types
J Appl Physiol, February 1, 2007; 102(2): 573 - 581.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. B. Verdijk, R. Koopman, G. Schaart, K. Meijer, H. H. C. M. Savelberg, and L. J. C. van Loon
Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E151 - E157.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. C. Kostek, M. J. Delmonico, J. B. Reichel, S. M. Roth, L. Douglass, R. E. Ferrell, and B. F. Hurley
Muscle strength response to strength training is influenced by insulin-like growth factor 1 genotype in older adults
J Appl Physiol, June 1, 2005; 98(6): 2147 - 2154.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. Thomson and S. E. Gordon
Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation
J Appl Physiol, February 1, 2005; 98(2): 557 - 564.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. K. Roberts and R. J. Barnard
Effects of exercise and diet on chronic disease
J Appl Physiol, January 1, 2005; 98(1): 3 - 30.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. M. Bamman, R. C. Ragan, J.-s. Kim, J. M. Cross, V. J. Hill, S. C. Tuggle, and R. M. Allman
Myogenic protein expression before and after resistance loading in 26- and 64-yr-old men and women
J Appl Physiol, October 1, 2004; 97(4): 1329 - 1337.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P.-S. Leung, W. J. Aronson, T. H. Ngo, L. A. Golding, and R. J. Barnard
Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro
J Appl Physiol, February 1, 2004; 96(2): 450 - 454.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
M. M. Bamman, V. J. Hill, G. R. Adams, F. Haddad, C. J. Wetzstein, B. A. Gower, A. Ahmed, and G. R. Hunter
Gender Differences in Resistance-Training-Induced Myofiber Hypertrophy Among Older Adults
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2003; 58(2): B108 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. E. Spangenburg, T. Abraha, T. E. Childs, J. S. Pattison, and F. W. Booth
Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent
Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E340 - E350.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. B. P. Charge, A. S. Brack, and S. M. Hughes
Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy
Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1228 - C1241.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
C. Castaneda, P. L. Gordon, K. L. Uhlin, A. S. Levey, J. J. Kehayias, J. T. Dwyer, R. A. Fielding, R. Roubenoff, and M. F. Singh
Resistance Training To Counteract the Catabolism of a Low-Protein Diet in Patients with Chronic Renal Insufficiency: A Randomized, Controlled Trial
Ann Intern Med, December 4, 2001; 135(11): 965 - 976.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. J. Carlson, Z. Fan, S. E. Gordon, and F. W. Booth
Time course of the MAPK and PI3-kinase response within 24 h of skeletal muscle overload
J Appl Physiol, November 1, 2001; 91(5): 2079 - 2087.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Hakkinen, A. Pakarinen, W. J. Kraemer, A. Hakkinen, H. Valkeinen, and M. Alen
Selective muscle hypertrophy, changes in EMG and force, and serum hormones during strength training in older women
J Appl Physiol, August 1, 2001; 91(2): 569 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Trappe, M. Godard, P. Gallagher, C. Carroll, G. Rowden, and D. Porter
Resistance training improves single muscle fiber contractile function in older women
Am J Physiol Cell Physiol, August 1, 2001; 281(2): C398 - C406.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. M. Bamman, J. R. Shipp, J. Jiang, B. A. Gower, G. R. Hunter, A. Goodman, C. L. McLafferty Jr., and R. J. Urban
Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans
Am J Physiol Endocrinol Metab, March 1, 2001; 280(3): E383 - E390.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
L. L. Ploutz-Snyder, E. L. Yackel-Giamis, A. E. Rosenbaum, and M. Formikell
Use of Muscle Functional Magnetic Resonance Imaging With Older Individuals
J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2000; 55(10): 504B - 511.
[Abstract] [Full Text]

Home page
 J. Am. Coll. Nutr.Home page
P. W.R. Lemon
Beyond the Zone: Protein Needs of Active Individuals
J. Am. Coll. Nutr., October 1, 2000; 19(90005): 513S - 521.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. Gallagher, A. J. Kovera, G. Clay-Williams, D. Agin, P. Leone, J. Albu, D. E. Matthews, and S. B. Heymsfield
Weight loss in postmenopausal obesity: no adverse alterations in body composition and protein metabolism
Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E124 - E131.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. M. Roth, M. A. Rogers;, and W. J. Evans
Interpretation of Muscle Damage From Fixed Tissue Obtained by Needle Biopsy
Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E754 - E756.
[Full Text]

Home page
 J. Appl. Physiol.Home page
S. M. Roth, G. F. Martel, F. M. Ivey, J. T. Lemmer, E. J. Metter, B. F. Hurley, and M. A. Rogers
High-volume, heavy-resistance strength training and muscle damage in young and older women
J Appl Physiol, March 1, 2000; 88(3): 1112 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. A. Ferrando, M. Sheffield-Moore, C. W. Yeckel, C. Gilkison, J. Jiang, A. Achacosa, S. A. Lieberman, K. Tipton, R. R. Wolfe, and R. J. Urban
Testosterone administration to older men improves muscle function: molecular and physiological mechanisms
Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E601 - E607.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online