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Am J Physiol Endocrinol Metab 276: E1105-E1111, 1999;
0193-1849/99 $5.00
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Vol. 276, Issue 6, E1105-E1111, June 1999

Peripheral injection of growth hormone stimulates protein intake in aged male and female Lou rats

Christelle Veyrat-Durebex1, Pierrette Gaudreau2, Veronique Coxam3, Nathalie Gaumet3, and Josette Alliot1

1 Psychophysiologie et Neuroendocrinologie, Complexe scientifique des cézeaux, Université Blaise Pascal, 63177 Aubière; 3 Métabolisme minéral, Institut National de la Recherche Agronomique Clermont-Theix, 63122 Ceyrat, France; and 2 Neuroendocrinologie du vieillissement, Centre Hospitalier de l'Université de Montréal, Pavillon Notre-Dame, Montréal, Québec, Canada H2L 4M1

It is well established that growth hormone (GH) induces growth rate and food efficiency and stimulates protein accretion in young mammals. Senescence is characterized by metabolic and hormonal disorders, particularly a decrease in protein turnover, which could be correlated to a decrease in GH and insulin-like growth factor I (IGF-I) secretion. We have shown that body weight, protein intake, and IGF-I plasma levels are greatly decreased with aging in Lou/C rats, particularly in males. In order to specify the GH effect on protein intake during aging, males and females (6, 19, and 24 mo) placed on a self-selection regimen were injected daily with a physiological dose of human GH (0.023 mg/rat sc). No GH effect on caloric intake was observed. Nevertheless, GH treatment stimulated body weight in older rats. It also increased protein intake in females and older males (19-24 mo). This stimulating effect was positively correlated with the degree of weight loss in senescent rats, suggesting that the decrease in protein intake observed with aging could be a marker of senescence.

aging; protein selection; body weight


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J. Alliot, S. Boghossian, D. Jourdan, C. Veyrat-Durebex, G. Pickering, D. Meynial-Denis, and N. Gaumet
The LOU/c/jall Rat as an Animal Model of Healthy Aging?
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2002; 57(8): B312 - 320.
[Abstract] [Full Text] [PDF]


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