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Department of Human Biology, Nutrition Research Centre, Maastricht University, 6200 MD Maastricht, The Netherlands
The purposes of this
study were 1) to investigate the
effect of carbohydrate (CHO) ingestion on endogenous glucose production (EGP) during prolonged exercise, 2)
to study whether glucose appearance in the circulation could be a
limiting factor for exogenous CHO oxidation, and
3) to investigate whether large CHO
feedings can reduce muscle glycogen oxidation during exercise. Six
well-trained subjects exercised three times for 120 min at 50% maximum
workload while ingesting water (FAST), a 4% glucose solution (LO-Glc), or a 22% glucose solution (HI-Glc). A primed continuous intravenous [6,6-2H2]glucose
infusion was given, and the ingested glucose was enriched with
[U-13C]glucose.
Glucose ingestion significantly elevated CHO oxidation as well as the
rates of appearance (Ra) and
disappearance. Ra glucose equaled
Ra of glucose in gut
(Ra gut) during HI-Glc, whereas EGP was completely suppressed. During LO-Glc, EGP was partially suppressed, whereas Ra gut
provided most of the total glucose Ra. We conclude that
1) high rates of CHO ingestion can
completely block EGP, 2)
Ra gut may be a limiting factor
for exogenous CHO oxidation, and 3)
muscle glycogen oxidation was not reduced by large glucose feedings.
stable isotopes; glucose kinetics; glycogen; endogenous glucose output; glucose metabolism; sport nutrition
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