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1 Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1; and 2 Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11749-8661
We have examined
whether 1) fatty acid (FA) uptake,
2) FA transporter expression, and
3) FA metabolism are increased when the oxidative capacity of skeletal muscle is increased. The oxidative capacities of red and white tibialis anterior and extensor digitorum longus muscles were increased via chronic stimulation (10 Hz, 24 h/day
for 7 days). The contralateral muscles served as controls. After 7 days
of increased muscle activity 1)
palmitate uptake by giant sarcolemmal vesicles was increased twofold
(P < 0.05), 2) the expression of FA translocase
(FAT)/CD36 was increased at both the mRNA (3.2- to
10-fold) and protein (3.4-fold) levels, and
3) palmitate oxidation and
esterification into triacylglycerols and phospholipids were increased
1.5-, 2.7-, and 1.7-fold, respectively (P < 0.05). These data show that
when the oxidative capacity of muscle is increased, there is a parallel
increase in the rate of FA transport and FA transporters at the
sarcolemmal membrane, which is associated with the enhanced expression
of the membrane transporter FAT/CD36.
palmitate; giant sarcolemmal vesicles; oxidation; phospholipids; muscle fibers; fatty acid translocase
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