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Am J Physiol Endocrinol Metab 276: E620-E627, 1999;
0193-1849/99 $5.00
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Vol. 276, Issue 4, E620-E627, April 1999

Depression of liver protein synthesis during surgery is prevented by growth hormone

Hans Barle1, Pia Essén1, Björn Nyberg2, Hans Olivecrona2, Michael Tally3, Margaret A. McNurlan4, Jan Wernerman1, and Peter J. Garlick4

1 Department of Anesthesiology and Intensive Care and 2 Department of Surgery, Huddinge University Hospital, S-141 86 Huddinge; 3 Department of Endocrinology, Karolinska Hospital, S-104 01 Stockholm, Sweden; and 4 Department of Surgery, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8191

This study was undertaken to elucidate the specific effects of growth hormone (GH) on liver protein metabolism in humans during surgery. Otherwise healthy patients scheduled for elective laparoscopic cholecystectomy were randomized into controls (n = 9) or pretreatment with 12 units of GH for 1 day (GH 1, n = 9) or daily for 5 days (GH 5, n = 10). The fractional synthesis rate of liver proteins, as assessed by flooding with [2H5]phenylalanine, was higher in the GH 5 group (22.0 ± 6.9%/day, mean ± SD, P < 0.05) than in the control (16.1 ± 3.1%/day) and GH 1 (16.5 ± 5.5%/day) groups. During surgery, the fraction of polyribosomes in the liver, as assessed by ribosome analysis, decreased in the control group by ~12% (P < 0.01) but did not decrease in the GH-treated groups. In addition, the concentrations of the essential amino acids and aspartate in the liver decreased in response to GH treatment. In conclusion, GH pretreatment decreases hepatic free amino acid concentrations and preserves liver protein synthesis during surgery.

hepatic; laparoscopy; mass spectrometry; stable isotopes


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H. Barle, B. Nyberg, S. Ramel, P. Essen, M. A. McNurlan, J. Wernerman, and P. J. Garlick
Inhibition of liver protein synthesis during laparoscopic surgery
Am J Physiol Endocrinol Metab, October 1, 1999; 277(4): E591 - E596.
[Abstract] [Full Text] [PDF]


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