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Metabolism Unit, Shriners Burns Institute, and the Departments of Surgery, Anesthesiology, and Internal Medicine, The University of Texas Medical Branch, Galveston, Texas 77550
The effects of combined
hyperglycemia-hyperinsulinemia on whole body, splanchnic, and leg fatty
acid metabolism were determined in five volunteers. Catheters were
placed in a femoral artery and vein and a hepatic vein.
U-13C-labeled fatty acids were
infused, once in the basal state and, on a different occasion, during
infusion of dextrose (clamp; arterial glucose 8.8 ± 0.5 mmol/l).
Lipids and heparin were infused together with the dextrose to maintain
plasma fatty acid concentrations at basal levels. Fatty acid
availability in plasma and fatty acid uptake across the splanchnic
region and the leg were similar during the basal and clamp experiments.
Dextrose infusion decreased fatty acid oxidation by 51.8% (whole
body), 47.4% (splanchnic), and 64.3% (leg). Similarly, the percent
fatty acid uptake oxidized decreased at the whole body level (53 to
29%), across the splanchnic region (30 to 13%), and in the leg (48 to
22%) during the clamp. We conclude that, in healthy men, combined
hyperglycemia-hyperinsulinemia inhibits fatty acid oxidation to a
similar extent at the whole body level, across the leg, and across the
splanchnic region, even when fatty acid availability is constant.
liver; blood flow; hepatic vein; diabetes; obesity
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