AJP - Endo Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 276: E295-E302, 1999;
0193-1849/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moore, M. C.
Right arrow Articles by Cherrington, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moore, M. C.
Right arrow Articles by Cherrington, A. D.
Vol. 276, Issue 2, E295-E302, February 1999

Differential effect of amino acid infusion route on net hepatic glucose uptake in the dog

Mary Courtney Moore1, Po-Shiuan Hsieh1, Paul J. Flakoll2, Doss W. Neal2, and Alan D. Cherrington1,2

1 Department of Molecular Physiology and Biophysics, and 2 Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6015

Concomitant portal infusion of gluconeogenic amino acids (GNGAA) and glucose significantly reduces net hepatic glucose uptake (NHGU), in comparison with NHGU during portal infusion of glucose alone. To determine whether this effect on NHGU is specific to the portal route of GNGAA delivery, somatostatin, intraportal insulin (3-fold basal) and glucagon (basal), and intraportal glucose (to increase the hepatic glucose load by ~50%) were infused for 240 min. GNGAA were infused peripherally into a group of dogs (PeAA), at a rate to match the hepatic GNGAA load in a group of dogs that were given the same GNGAA mixture intraportally (PoAA) at 7.6 µmol · kg-1 · min-1 (9). The arterial blood glucose concentrations and hepatic glucose loads were the same in the two groups, but NHGU (-0.9 ± 0.2 PoAA and -2.1 ± 0.5 mg · kg-1 · min-1 in PeAA, P < 0.05) and net hepatic fractional extraction of glucose (2.6 ± 0.7% in PoAA vs. 5.9 ± 1.4% in PeAA, P < 0.05) differed. Neither the hepatic loads nor the net hepatic uptakes of GNGAA were significantly different in the two groups. Net hepatic glycogen synthesis was ~2.5-fold greater in PeAA than PoAA (P < 0.05). Intraportal, but not peripheral, amino acid infusion suppresses NHGU and net hepatic glycogen synthesis in response to intraportal glucose infusion.

liver; hyperglycemia; liver nerves; glycogen; portal vein


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. J. Winnick, Z. An, M. C. Moore, C. J. Ramnanan, B. Farmer, M. Shiota, and A. D. Cherrington
A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin
Am J Physiol Endocrinol Metab, August 1, 2009; 297(2): E358 - E366.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
Z. An, C. A. DiCostanzo, M. C. Moore, D. S. Edgerton, D. P. Dardevet, D. W. Neal, and A. D. Cherrington
Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog
Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E300 - E306.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S.-S. Chen, C. J Torres-Sanchez, N. Hosein, Y. Zhang, D. B. Lacy, C. Chang, and O. P. McGuinness
Route-dependent effect of nutritional support on liver glucose uptake
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1319 - R1327.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. C. Moore, P.-S. Hsieh, P. J. Flakoll, D. W. Neal, and A. D. Cherrington
Net Hepatic Gluconeogenic Amino Acid Uptake in Response to Peripheral versus Portal Amino Acid Infusion in Conscious Dogs
J. Nutr., December 1, 1999; 129(12): 2218 - 2224.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online