AJP - Endo Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 276: E163-E170, 1999;
0193-1849/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jackson, N. C.
Right arrow Articles by Umpleby, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jackson, N. C.
Right arrow Articles by Umpleby, A. M.
Vol. 276, Issue 1, E163-E170, January 1999

The metabolic consequences of critical illness: acute effects on glutamine and protein metabolism

N. C. Jackson1, P. V. Carroll1, D. L. Russell-Jones1, P. H. Sönksen1, D. F. Treacher2, and A. M. Umpleby1

Departments of 1 Diabetes, Endocrinology and Metabolic Medicine and 2 Intensive Care, St. Thomas' Hospital, London SE1 7EH, United Kingdom

Net protein loss and large decreases in plasma glutamine concentration are characteristics of critical illness. We have used [2-15N]glutamine and [1-13C]leucine to investigate whole body glutamine and leucine kinetics in a group of critically ill patients and matched healthy controls. Glutamine appearance rate (Ra,Gln) was similar in both groups. However, in the patients, the proportion of Ra,Gln arising from protein breakdown was higher than in the control group (43 ± 3 vs. 32 ± 2%, P < 0.05). Glutamine metabolic clearance rate (MCR) was 92 ± 8% higher (P < 0.001), whereas plasma glutamine concentration was 38 ± 5% lower (P < 0.001) than in the control group. Leucine appearance rate (whole body proteolysis) and nonoxidative leucine disposal (whole body protein synthesis) were 59 ± 14 and 49 ± 15% higher in the patients (P < 0.001). Leucine oxidation and MCR were increased in the patients by 104 ± 37 and 129 ± 39%, respectively (P < 0.05). These results demonstrate that critical illness is associated with a major increase in protein turnover. The acute decrease in plasma glutamine concentration and the unaltered plasma Ra,Gln suggest that the increase in proteolysis is insufficient to meet increased demand for glutamine in this severe catabolic state.

stable isotopes; leucine; age


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. Thibault, S. Welch, N. Mauras, B. Sager, A. Altomare, M. Haymond, and D. Darmaun
Corticosteroids increase glutamine utilization in human splanchnic bed
Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G548 - G553.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
E. L. Burnham, M. Moss, and T. R. Ziegler
Myopathies in Critical Illness: Characterization and Nutritional Aspects
J. Nutr., July 1, 2005; 135(7): 1818S - 1823S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. V. Carroll, N. C. Jackson, D. L. Russell-Jones, D. F. Treacher, P. H. Sonksen, and A. M. Umpleby
Combined growth hormone/insulin-like growth factor I in addition to glutamine-supplemented TPN results in net protein anabolism in critical illness
Am J Physiol Endocrinol Metab, January 1, 2004; 286(1): E151 - E157.
[Abstract] [Full Text]

Home page
 DiabetesHome page
A. Battezzati, A. Caumo, A. Fattorini, L. P. Sereni, J. Coppa, R. Romito, M. Ammatuna, E. Regalia, V. Mazzaferro, and L. Luzi
Amino Acid Kinetics During the Anhepatic Phase of Liver Transplantation
Diabetes, June 1, 2002; 51(6): 1690 - 1698.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
T. Planche, A. Dzeing, A.C. Emmerson, M. Onanga, P.G. Kremsner, K. Engel, M. Kombila, E. Ngou-Milama, and S. Krishna
Plasma glutamine and glutamate concentrations in Gabonese children with Plasmodium falciparum infection
QJM, February 1, 2002; 95(2): 89 - 97.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
V. R. Young and A. M. Ajami
Glutamine: The Emperor or His Clothes?
J. Nutr., September 1, 2001; 131(9): 2449S - 2459.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
G. E. Lobley, S. O. Hoskin, and C. J. McNeil
Glutamine in Animal Science and Production
J. Nutr., September 1, 2001; 131(9): 2525S - 2531.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. J. Bruins, P. B. Soeters, and N. E. P. Deutz
Endotoxemia Affects Organ Protein Metabolism Differently during Prolonged Feeding in Pigs
J. Nutr., December 1, 2000; 130(12): 3003 - 3013.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
B. A. C. van Acker, K. W. E. Hulsewé, A. J. M. Wagenmakers, P. B. Soeters, and M. F. von Meyenfeldt
Glutamine Appearance Rate in Plasma Is Not Increased after Gastrointestinal Surgery in Humans
J. Nutr., June 1, 2000; 130(6): 1566 - 1571.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
C. C. Metges and C. A. Barth
Metabolic Consequences of a High Dietary-Protein Intake in Adulthood: Assessment of the Available Evidence
J. Nutr., April 1, 2000; 130(4): 886 - 889.
[Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. C. Jackson, P. V. Carroll, D. L. Russell-Jones, P. H. Sonksen, D. F. Treacher, and A. M. Umpleby
Effects of glutamine supplementation, GH, and IGF-I on glutamine metabolism in critically ill patients
Am J Physiol Endocrinol Metab, February 1, 2000; 278(2): E226 - E233.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online