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Am J Physiol Endocrinol Metab 275: E987-E992, 1998;
0193-1849/98 $5.00
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Vol. 275, Issue 6, E987-E992, December 1998

Hepatic glucose uptake rapidly decreases after removal of the portal signal in conscious dogs

Po-Shiuan Hsieh, Mary Courtney Moore, Doss W. Neal, and Alan D. Cherrington

Department of Molecular Physiology and Biophysics and Diabetes Research and Training Center, Vanderbilt University, Nashville, Tennessee 37232-0615

The aim of this study was to assess the decay of the effect of the portal signal on net hepatic glucose uptake (NHGU). Experiments were performed on five 42-h-fasted conscious dogs. After the 40-min basal period, somatostatin was given peripherally along with insulin (1.8 pmol · kg-1 · min-1) and glucagon (0.65 ng · kg-1 · min-1) intraportally. In the first experimental period (Pe-GLU-1; 90 min), glucose was infused into a peripheral vein to double the glucose load to the liver (HGL). In the second experimental period (Po-GLU; 90 min), glucose (20.1 µmol · kg-1 · min-1) was infused intraportally and the peripheral glucose infusion was reduced to maintain the same HGL. In the third period (Pe-GLU-2; 120 min), the portal glucose infusion was stopped and the peripheral glucose infusion was increased to again sustain HGL. Arterial insulin levels (42 ± 3, 47 ± 3, 43 ± 3 pmol/l) were basal and similar in the Pe-GLU-1, Po-GLU, and Pe-GLU-2 periods, respectively. Arterial glucagon levels were also basal and similar (51 ± 3, 49 ± 2, 46 ± 2 ng/l) in the three experimental periods. The glucose loads to the liver were 251 ± 11, 274 ± 14, and 276 ± 12 µmol · kg-1 · min-1, respectively. NHGU was 6.3 ± 2.4, 19.1 ± 2.8, and 9.2 ± 1.2 µmol · kg-1 · min-1, and nonhepatic glucose uptake (non-HGU) was 23.6 ± 3.0, 5.3 ± 1.8, and 25.5 ± 3.7 µmol · kg-1 · min-1 in the three periods, respectively. Cessation of the portal signal for only 10 min shifted NHGU and non-HGU to 9.4 ± 2.2 and 25.0 ± 2.8 µmol · kg-1 · min-1, respectively; thus the effect of the portal signal was rapidly reversed both at the liver and peripheral tissues.

glucose; liver; liver nerve


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