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1 Laboratoire des Adaptations de l'Organisme à l'Exercice Musculaire, Hôpital Purpan, 31059 Toulouse Cedex, France; 2 Institut National de la Santé et de la Recherche Médicale Unité 317, Université Paul Sabatier, 31062 Toulouse Cedex 4, France; and 3 Department of Sport Medicine, Third Faculty of Medicine, Charles University, 10 000 Prague 10, Czech Republic
The aim of this study was to investigate the
effect of aerobic exercise training on the lipolytic response of
adipose tissue in obese subjects. Thirteen men (body mass index = 36.9 ± 1.3 kg/m2) were submitted
to aerobic physical training on a cycloergometer (30-45 min, 4 days a wk) for 3 mo. Adipocyte sensitivity to the action of
catecholamines and insulin was studied in vitro before and after
training. Training induced a decrease in the percentage of fat mass
(P < 0.05) without changing the body
weight. Basal lipolysis and hormone-sensitive lipase activity were
significantly decreased after training
(P < 0.05). The lipolytic effects of epinephrine, isoprenaline (
-adrenoceptor agonist), and dobutamine (1-adrenoceptor agonist) were
significantly increased (P < 0.05) but not those of procaterol
(2-adrenoceptor agonist). The
antilipolytic effects of
2-adrenoceptor and insulin were
significantly decreased (P < 0.05).
Lipolysis stimulation by agents acting at the postreceptor level was
unchanged after training. In conclusion, aerobic physical training in
obese male subjects modifies adipose tissue lipolysis through an
enhancement of -adrenergic response and a concomitant blunting of
adipocyte antilipolytic activity.
adipose tissue biopsy; catecholamines; insulin; hormone-sensitive lipase
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