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Am J Physiol Endocrinol Metab 275: E909-E916, 1998;
0193-1849/98 $5.00
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Vol. 275, Issue 6, E909-E916, December 1998

beta -Adrenergic regulation of lipolysis and blood flow in human skeletal muscle in vivo

Eva Hagström-Toft1, Staffan Enoksson2, Erik Moberg1, Jan Bolinder1, and Peter Arner1

1 Department of Medicine and Research Center, 2 Department of Vascular Surgery, Huddinge Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden

Little is known about the regulation of catecholamine-stimulated lipolysis in human skeletal muscle. Therefore, beta -adrenergic regulation of lipolysis and blood flow was investigated in healthy subjects in vivo by use of microdialysis of the gastrocnemius muscle. First, during a hypoglycemic, hyperinsulinemic clamp, which induces a lipolytic response in skeletal muscle tissue, the muscle was locally perfused with beta -adrenoceptor blocking agents. Perfusion with nonselective (propranolol) and beta 2-selective (ICI-118551) blocking agents counteracted the hypoglycemia-induced lipolysis (P < 0.01), but perfusion with metoprolol (beta 1-blocker) did not affect the glycerol response. Second, selective beta -adrenoceptor agonists were perfused in situ into skeletal muscle during resting conditions. beta 2-Adrenoceptor stimulation with terbutaline induced a concentration-dependent increase in skeletal muscle glycerol levels and in tissue blood flow, whereas perfusion with beta 1- or beta 3-adrenoceptor agonists (dobutamine or CGP-12177) did not influence the glycerol concentration or blood flow. In conclusion, in skeletal muscle tissue, only the beta 2-subtype is of importance among beta -adrenoceptors for regulation of lipolysis and blood flow. This is in contrast to adipose tissue, where beta 1- and beta 3-adrenoceptors are also involved.

beta -adrenoceptors; insulin; glycerol; microdialysis; hypoglycemia


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