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Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California 94720-3140
We examined the effects of exercise intensity and training
[12 wk, 5 days/wk, 1 h, 75% peak oxygen consumption
(
O2 peak)] on
lipolysis and plasma free fatty acid (FFA) flux in women
(n = 8; 24.3 ± 1.6 yr). Two
pretraining trials (45 and 65% of
O2 peak) and two posttraining trials [same absolute workload (65% of old O2 peak;
ABT) and same relative workload (65% of new
O2 peak; RLT)] were performed using infusions of
[1,1,2,3,3-2H]glycerol
and [1-13C]palmitate.
Pretraining rates of FFA appearance
(Ra), disappearance (Rd), and oxidation
(Rox p) were similar
between the 65% (6.8 ± 0.6, 6.2 ± 0.7, 3.1 ± 0.3 µmol · kg
1 · min1,
respectively) and the 45% of
O2 peak
trials. At ABT and RLT training increased FFA
Ra to 8.4 ± 1.0 and 9.7 ± 1.1 µmol · kg1 · min1,
Rd to 8.3 ± 1.0 and 9.5 ± 1.1 µmol · kg1 · min1,
and Rox p to 4.8 ± 0.4 and 6.7 ± 0.7 µmol · kg1 · min1,
respectively (P 
0.05). Total FFA
oxidation from respiratory exchange ratio was also elevated after
training at ABT and RLT, with all of the increase attributed to
plasma FFA sources. Pretraining, glycerol
Ra was higher during exercise at
65 than 45% of O2 peak (6.9 ± 0.9 vs. 4.7 ± 0.6 µmol · kg1 · min1)
but was not changed by training. In young women
1) plasma FFA kinetics and oxidation
are not linearly related to exercise intensity before training,
2) training increases FFA
Ra, Rd, and Rox p whether measured at given absolute or relative exercise intensities,
3) whole body lipolysis (glycerol
Ra) during exercise is not
significantly impacted by training, and
4) training-induced increases in
plasma FFA oxidation are the main contributor to elevated total FFA
oxidation during exercise exertion after training.
stable isotopes; substrate utilization; fat metabolism; glycerol; reesterification; lipolysis; crossover concept; gender; exertion
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