| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California 94720-3140
We examined the effects of exercise intensity and training
[12 wk, 5 days/wk, 1 h, 75% peak oxygen consumption
(
O2 peak)] on
lipolysis and plasma free fatty acid (FFA) flux in women
(n = 8; 24.3 ± 1.6 yr). Two
pretraining trials (45 and 65% of
O2 peak) and two posttraining trials [same absolute workload (65% of old O2 peak;
ABT) and same relative workload (65% of new
O2 peak; RLT)] were performed using infusions of
[1,1,2,3,3-2H]glycerol
and [1-13C]palmitate.
Pretraining rates of FFA appearance
(Ra), disappearance (Rd), and oxidation
(Rox p) were similar
between the 65% (6.8 ± 0.6, 6.2 ± 0.7, 3.1 ± 0.3 µmol · kg
1 · min1,
respectively) and the 45% of
O2 peak
trials. At ABT and RLT training increased FFA
Ra to 8.4 ± 1.0 and 9.7 ± 1.1 µmol · kg1 · min1,
Rd to 8.3 ± 1.0 and 9.5 ± 1.1 µmol · kg1 · min1,
and Rox p to 4.8 ± 0.4 and 6.7 ± 0.7 µmol · kg1 · min1,
respectively (P 
0.05). Total FFA
oxidation from respiratory exchange ratio was also elevated after
training at ABT and RLT, with all of the increase attributed to
plasma FFA sources. Pretraining, glycerol
Ra was higher during exercise at
65 than 45% of O2 peak (6.9 ± 0.9 vs. 4.7 ± 0.6 µmol · kg1 · min1)
but was not changed by training. In young women
1) plasma FFA kinetics and oxidation
are not linearly related to exercise intensity before training,
2) training increases FFA
Ra, Rd, and Rox p whether measured at given absolute or relative exercise intensities,
3) whole body lipolysis (glycerol
Ra) during exercise is not
significantly impacted by training, and
4) training-induced increases in
plasma FFA oxidation are the main contributor to elevated total FFA
oxidation during exercise exertion after training.
stable isotopes; substrate utilization; fat metabolism; glycerol; reesterification; lipolysis; crossover concept; gender; exertion
This article has been cited by other articles:
|
|
 |
|
  K. Vissing, S. L. McGee, C. Roepstorff, P. Schjerling, M. Hargreaves, and B. Kiens Effect of sex differences on human MEF2 regulation during endurance exercise Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E408 - E415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Henderson, J. A. Fattor, M. A. Horning, N. Faghihnia, M. L. Johnson, T. L. Mau, M. Luke-Zeitoun, and G. A. Brooks Lipolysis and fatty acid metabolism in men and women during the postexercise recovery period J. Physiol., November 1, 2007; 584(3): 963 - 981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Friedlander, K. A. Jacobs, J. A. Fattor, M. A. Horning, T. A. Hagobian, T. A. Bauer, E. E. Wolfel, and G. A. Brooks Contributions of working muscle to whole body lipid metabolism are altered by exercise intensity and training Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E107 - E116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Kevin. A. Jacobs, R. M. Krauss, J. A. Fattor, M. A. Horning, A. L. Friedlander, T. A. Bauer, T. A. Hagobian, E. E. Wolfel, and G. A. Brooks Endurance training has little effect on active muscle free fatty acid, lipoprotein cholesterol, or triglyceride net balances Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E656 - E665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Horton, G. K. Grunwald, J. Lavely, and W. T. Donahoo Glucose kinetics differ between women and men, during and after exercise J Appl Physiol, June 1, 2006; 100(6): 1883 - 1894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Horton, E. K. Miller, and K. Bourret No effect of menstrual cycle phase on glycerol or palmitate kinetics during 90 min of moderate exercise J Appl Physiol, March 1, 2006; 100(3): 917 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kiens Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance Physiol Rev, January 1, 2006; 86(1): 205 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Kuo, J. A. Fattor, G. C. Henderson, and G. A. Brooks Lipid oxidation in fit young adults during postexercise recovery J Appl Physiol, July 1, 2005; 99(1): 349 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Jacobs, G. A. Casazza, S.-H. Suh, M. A. Horning, and G. A. Brooks Fatty acid reesterification but not oxidation is increased by oral contraceptive use in women J Appl Physiol, May 1, 2005; 98(5): 1720 - 1731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Venables, J. Achten, and A. E. Jeukendrup Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study J Appl Physiol, January 1, 2005; 98(1): 160 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. C. van Loon Use of intramuscular triacylglycerol as a substrate source during exercise in humans J Appl Physiol, October 1, 2004; 97(4): 1170 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. de Glisezinski, C. Moro, F. Pillard, F. Marion-Latard, I. Harant, M. Meste, M. Berlan, F. Crampes, and D. Riviere Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E984 - E990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Tunstall, K. A. Mehan, G. D. Wadley, G. R. Collier, A. Bonen, M. Hargreaves, and D. Cameron-Smith Exercise training increases lipid metabolism gene expression in human skeletal muscle Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E66 - E72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. C. Van Aggel-Leijssen, W. H. M. Saris, A. J. M. Wagenmakers, J. M. Senden, and M. A. Van Baak Effect of exercise training at different intensities on fat metabolism of obese men J Appl Physiol, March 1, 2002; 92(3): 1300 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Roepstorff, C. H. Steffensen, M. Madsen, B. Stallknecht, I.-L. Kanstrup, E. A. Richter, and B. Kiens Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E435 - E447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. W. Lange, J. Lorentsen, F. Isaksson, A. Juul, M. H. Rasmussen, N. J. Christensen, J. Bulow, and M. Kjar Endurance training and GH administration in elderly women: effects on abdominal adipose tissue lipolysis Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E886 - E897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Carter, C. Rennie, and M. A. Tarnopolsky Substrate utilization during endurance exercise in men and women after endurance training Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E898 - E907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Goedecke, A. S. C. Gibson, L. Grobler, M. Collins, T. D. Noakes, and E. V. Lambert Determinants of the variability in respiratory exchange ratio at rest and during exercise in trained athletes Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1325 - E1334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Enevoldsen, B. Stallknecht, J. D. Fluckey, and H. Galbo Effect of exercise training on in vivo lipolysis in intra-abdominal adipose tissue in rats Am J Physiol Endocrinol Metab, September 1, 2000; 279(3): E585 - E592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Horowitz, T. C. Leone, W. Feng, D. P. Kelly, and S. Klein Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training Am J Physiol Endocrinol Metab, August 1, 2000; 279(2): E348 - E355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Goodpaster, D. E. Kelley, F. L. Thaete, J. He, and R. Ross Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content J Appl Physiol, July 1, 2000; 89(1): 104 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Romijn, E. F. Coyle, L. S. Sidossis, J. Rosenblatt, and R. R. Wolfe Substrate metabolism during different exercise intensities in endurance-trained women J Appl Physiol, May 1, 2000; 88(5): 1707 - 1714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mora-Rodriguez and E. F. Coyle Effects of plasma epinephrine on fat metabolism during exercise: interactions with exercise intensity Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E669 - E676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Friedlander, G. A. Casazza, M. A. Horning, A. Usaj, and G. A. Brooks Endurance training increases fatty acid turnover, but not fat oxidation, in young men J Appl Physiol, June 1, 1999; 86(6): 2097 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Bergman, G. E. Butterfield, E. E. Wolfel, G. A. Casazza, G. D. Lopaschuk, and G. A. Brooks Evaluation of exercise and training on muscle lipid metabolism Am J Physiol Endocrinol Metab, January 1, 1999; 276(1): E106 - E117. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
