AJP - Endo Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 275: E830-E834, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Coppack, S. W.
Right arrow Articles by Klein, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coppack, S. W.
Right arrow Articles by Klein, S.
Vol. 275, Issue 5, E830-E834, November 1998

Whole body, adipose tissue, and forearm norepinephrine kinetics in lean and obese women

Simon W. Coppack1, Jeffrey F. Horowitz2, Deanna S. Paramore2, Philip E. Cryer2, Henry D. Royal2, and Samuel Klein2

2 Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110; and 1 Department of Medicine, University College London Medical School, London N19 3UA, United Kingdom

We evaluated whole body and regional (subcutaneous abdominal adipose tissue and forearm) norepinephrine (NE) kinetics in seven lean (body mass index 21.3 ± 0.5 kg/m2) and six upper body obese (body mass index 36.4 ± 0.4 kg/m2) women who were matched on fat-free mass. NE kinetics were determined by infusing [3H]NE and obtaining blood samples from a radial artery, a deep forearm vein draining mostly skeletal muscle, and an abdominal vein draining subcutaneous abdominal fat. Mean systemic NE spillover tended to be higher in obese (2.82 ± 0.49 nmol/min) than in lean (2.53 ± 0.40 nmol/min) subjects, but the differences were not statistically significant. Adipose tissue and forearm NE spillover rates into plasma were greater in lean (0.91 ± 0.08 pmol · 100 g tissue-1 · min-1 and 1.01 ± 0.09 pmol · 100 ml tissue-1 · min-1, respectively) than in obese (0.26 ± 0.05 pmol · 100 g tissue-1 · min-1 and 0.58 ± 0.11 pmol · 100 ml tissue-1 · min-1, respectively) subjects (P < 0.01). These results demonstrate that adipose tissue is an active site for NE metabolism in humans. Adipose tissue NE spillover is considerably lower in obese than in lean women, which may contribute to the lower rate of lipolysis per kilogram of fat mass observed in obesity.

catecholamines; obesity; energy metabolism


This article has been cited by other articles:


Home page
 DiabetesHome page
J. M. Miles, D. Wooldridge, W. J. Grellner, S. Windsor, W. L. Isley, S. Klein, and W. S. Harris
Nocturnal and Postprandial Free Fatty Acid Kinetics in Normal and Type 2 Diabetic Subjects: Effects of Insulin Sensitization Therapy
Diabetes, March 1, 2003; 52(3): 675 - 681.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Klein, J. F. Horowitz, M. Landt, S. J. Goodrick, V. Mohamed-Ali, and S. W. Coppack
Leptin production during early starvation in lean and obese women
Am J Physiol Endocrinol Metab, February 1, 2000; 278(2): E280 - E284.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online