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Metabolism Unit, Shriners Burns Institute; and Departments of Surgery, Anesthesiology, and Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77550
The effect of
hyperglycemia (~8 mmol/l) on splanchnic fatty acid oxidation and
triacylglycerol (TG) secretion rates was investigated in five healthy
men. U-13C-labeled fatty acids
were infused to estimate fatty acid kinetics and oxidation across the
splanchnic region, and in vivo labeled very low density lipoprotein
(VLDL)-TG was infused to estimate TG secretion rate. Plasma fatty acid
carbon enrichment and concentration were maintained constant by
infusion of lipids and heparin in the hyperglycemia experiments. Fatty
acid uptake by the splanchnic region was 1.4 ± 0.2 and 2.2 ± 0.9 µmol · kg
1 · min1
in the basal and clamp experiments, respectively, whereas fatty acid
oxidation decreased from 0.4 ± 0.04 to 0.2 ± 0.05 µmol · kg1 · min1
(P < 0.05). Hepatic TG secretion
increased from 0.35 ± 0.07 µmol · kg1 · min1
in the basal state to 0.53 ± 0.11 µmol · kg1 · min1
after 15 h of hyperglycemia (P < 0.05). Similarly, plasma VLDL-TG concentration increased from
0.28 ± 0.06 to 0.43 ± 0.05 mmol/l during the clamp
(P < 0.05). In summary,
hyperglycemia attenuates fatty acid oxidation in the splanchnic region
in human volunteers, even when fatty acid availability is constant.
This adaptation results in a significant increase in the VLDL-TG
secretion rate and concentration in plasma.
liver; blood flow; hepatic vein; malonyl-coenzyme A; carnitine palmitoyltransferase; diabetes; obesity
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