AJP - Endo AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 275: E785-E791, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dechenes, C. J.
Right arrow Articles by Kahn, S. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dechenes, C. J.
Right arrow Articles by Kahn, S. E.
Vol. 275, Issue 5, E785-E791, November 1998

Human aging is associated with parallel reductions in insulin and amylin release

Cynthia J. Dechenes, C. Bruce Verchere, Sofianos Andrikopoulos, and Steven E. Kahn

Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle 98195; and Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108

Aging is associated with an increased risk of type 2 diabetes. To determine whether the insulin resistance of aging is associated with an increase in amylin release or whether amylin release parallels the reduction in insulin release, we studied 10 older (72 ± 2 yr) and 9 young (25 ± 1 yr) subjects. Insulin sensitivity was quantified as the insulin sensitivity index (SI) and B cell function as the acute insulin and amylin responses to iv glucose (AIRg and AARg, respectively) and iv arginine at a glucose level of >25 mM (AIRmax and AARmax). To account for the effect of SI to modulate B cell function, we calculated SI × B cell function. Older subjects were insulin resistant (SI: 4.6 ± 0.8 vs. 8.6 ± 1.4 × 10-5 min-1/pM, P < 0.05). Acute responses to glucose [AIRg (older vs. young): 420 ± 106 vs. 537 ± 87 pM; AARg: 6.5 ± 1.7 vs. 9.0 ± 1.5 pM] and arginine (AIRmax: 1,096 ± 203 vs. 1,572 ± 307 pM; AARmax: 14.0 ± 3.5 vs. 16.5 ± 2.4 pM) did not differ despite the difference in SI. When adjusted for SI, insulin responses were reduced in older subjects (SI × AIRg: 1.54 ± 0.29 vs. 4.10 ± 0.63 × 10-2 min-1, P = 0.001; SI × AIRmax: 4.03 ± 0.52 vs. 12.7 ± 2.9 × 10-2 min-1, P < 0.01), as was amylin release (SI × AARg: 2.46 ± 0.59 vs. 6.85 ± 0.95 × 10-4 min-1, P < 0.001; SI × AARmax: 4.71 ± 0.52 vs. 13.5 ± 2.2 × 10-4 min-1, P < 0.001). Amylin and insulin release was proportionate, with a molar ratio of 1.5% in older and 1.4% in young subjects. Thus aging is associated with parallel impairments in the adaptation of insulin and amylin release to insulin resistance. It is unlikely that an alteration in amylin release contributes to the increased risk of type 2 diabetes.

islet amyloid polypeptide; glucose; B cell; insulin sensitivity; body adiposity


This article has been cited by other articles:


Home page
 DiabetesHome page
R. Basu, E. Breda, A. L. Oberg, C. C. Powell, C. Dalla Man, A. Basu, J. L. Vittone, G. G. Klee, P. Arora, M. D. Jensen, et al.
Mechanisms of the Age-Associated Deterioration in Glucose Tolerance: Contribution of Alterations in Insulin Secretion, Action, and Clearance
Diabetes, July 1, 2003; 52(7): 1738 - 1748.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
N. G. Knowles, M. A. Landchild, W. Y. Fujimoto, and S. E. Kahn
Insulin and Amylin Release Are Both Diminished in First-Degree Relatives of Subjects With Type 2 Diabetes
Diabetes Care, February 1, 2002; 25(2): 292 - 297.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. M. Grundy, I. J. Benjamin, G. L. Burke, A. Chait, R. H. Eckel, B. V. Howard, W. Mitch, S. C. Smith Jr, and J. R. Sowers
Diabetes and Cardiovascular Disease : A Statement for Healthcare Professionals From the American Heart Association
Circulation, September 7, 1999; 100(10): 1134 - 1146.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online