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Am J Physiol Endocrinol Metab 275: E709-E716, 1998;
0193-1849/98 $5.00
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Vol. 275, Issue 4, E709-E716, October 1998

Splanchnic retention of intraduodenal and intrajejunal glucose in healthy adults

G. Livesey1, P. D. G. Wilson2, M. A. Roe1, R. M. Faulks1, L. M. Oram1, J. C. Brown1, J. Eagles1, R. H. Greenwood3, and H. Kennedy4

Departments of 1 Nutrition, Diet, and Health and 2 Food Biophysics, Institute of Food Research, Norwich NR4 7UA; and Departments of 3 Medicine and 4 Gastroenterology, Norfolk and Norwich Hospital, Norwich NR1 3SR, United Kingdom

Estimates of the spanchnic retention and appearance in the systemic circulation of orally administered glucose vary among laboratories even after recently identified sources of error have been accounted for [Livesey, G., P. D. G. Wilson, J. R. Dainty, J. C. Brown, R. M. Faulks, M. A. Roe, T. A. Newman, J. Eagles, F. A. Mellon, and R. Greenwood. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E717-E728, 1998]. We questioned whether, in healthy humans, D-glucose delivered intraluminally to the midjejunum appeared systemically as extensively as that delivered intraduodenally. Subjects were infused over a period of 90 min with 50 g of glucose in 1 liter of isotonic saline (incorporating 0.5 g D-[13C6]glucose) per 70 kg of body weight. Infusions were via enteral tubes terminating ~15 and 100 cm postpylorus. The systemic appearance of glucose was monitored by means of a primed-continuous intravenous infusion of D-[6,6-2H2]glucose. Whereas 98 ± 2% (n = 7) of the duodenally infused glucose appeared in the systemic circulation, only 35 ± 9% (n = 7) of midjejunally infused glucose did so, implying that 65 ± 9% was retained in the splanchnic bed. Either glucose was less efficiently absorbed at the midintestinal site or hepatic glucose sequestration was increased 10-fold, or both. The proximal intestine plays a key role in the delivery of glucose to the systemic circulation, and the distal intestine potentially delivers more glucose to the liver.

stable isotopes; absorption; metabolism; modeling


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