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Research Department of Human Nutrition, Center for Food Research, The Royal Veterinary and Agricultural University, DK-1958 Frederiksberg, Denmark
Muscle fiber
morphology and activities of four key enzymes, as well as energy
metabolism, were determined in nine normal-weight postobese women and
nine matched control subjects. No differences in fiber type
composition, but a smaller mean fiber area and area of fiber types I
and IIb, were found in postobese compared with control subjects
(P < 0.05). The activities of
-hydroxyacyl-CoA dehydrogenase (HADH) and citrate synthase (CS) were
20% lower in postobese than in control subjects
(P < 0.05). However, the activities
of lactate dehydrogenase and lipoprotein lipase were not significantly
different between postobese and control subjects. Basal metabolic rate
and respiratory exchange ratio were also similar, but maximal oxygen
uptake (
O2 max)
tended to be lower in postobese than in control subjects
(P = 0.06). When adjustments were made
for differences in
O2 max, HADH and CS
were not different between postobese and control subjects. In
conclusion, these data suggest that smaller fiber areas and lower
enzyme activities, i.e., markers of aerobic capacity of skeletal
muscle, but not fiber composition, may be factors predisposing to
obesity.
aerobic capacity; -hydroxyacyl-CoA dehydrogenase; citrate
synthase; lactate dehydrogenase; lipoprotein lipase; basal metabolic
rate; diet
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