AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 275: E351-E358, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Strömmer, L.
Right arrow Articles by Zierath, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strömmer, L.
Right arrow Articles by Zierath, J. R.
Vol. 275, Issue 2, E351-E358, August 1998

Skeletal muscle insulin resistance after trauma: insulin signaling and glucose transport

Lisa Strömmer1, Johan Permert1, Urban Arnelo1, Camilla Koehler1, Bengt Isaksson1, Jörgen Larsson1, Inger Lundkvist1, Marie Björnholm2, Yuichi Kawano2, Harriet Wallberg-Henriksson2, and Juleen R. Zierath2

1 Arvid Wretlinds Laboratory for Metabolic and Nutritional Research, Department of Surgery, Karolinska Institute at Huddinge University Hospital, 141 86 Huddinge; and 2 Department of Clinical Physiology, Karolinska Institute at Karolinska Hospital, 171 77 Stockholm, Sweden

Surgical trauma induces peripheral insulin resistance; however, the cellular mechanism has not been fully elucidated. We examined the effects of surgical trauma on insulin receptor signaling and glucose transport in skeletal muscle, a tissue that plays a predominant role in maintaining glucose homeostasis. Surgical trauma was induced by intestinal resection in the rat. Receptor phosphorylation was not altered with surgical trauma. Phosphotyrosine-associated phosphatidylinositol (PI) 3-kinase association was increased by 60 and 82% compared with fasted and fed controls, respectively (P < 0.05). Similar results were observed for insulin receptor substrate-1-associated PI 3-kinase activity. Insulin-stimulated protein kinase B (Akt kinase) phosphorylation was increased by 2.2-fold after surgical trauma (P < 0.05). The hyperphosphorylation of Akt is likely to reflect amplification of PI 3-kinase after insulin stimulation. Submaximal rates of insulin-stimulated 3-O-methylglucose transport were reduced in trauma vs. fasted rats by 51 and 38% for 100 and 200 µU/ml of insulin, respectively (P < 0.05). In conclusion, insulin resistance in skeletal muscle after surgical trauma is associated with reduced glucose transport but not with impaired insulin signaling to PI 3-kinase or its downstream target, Akt. The surgical trauma model presented in this report provides a useful tool to further elucidate the molecular mechanism(s) underlying the development of insulin resistance after surgical trauma.

insulin receptor; phosphatidylinositol 3-kinase; Akt/protein kinase B; surgical stress


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. G. Cree and R. R. Wolfe
Postburn trauma insulin resistance and fat metabolism
Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E1 - E9.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. Jessen, R. Pold, E. S. Buhl, L. S. Jensen, O. Schmitz, and S. Lund
Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles
J Appl Physiol, April 1, 2003; 94(4): 1373 - 1379.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Hirose, M. Kaneki, H. Sugita, S. Yasuhara, and J. A. J. Martyn
Immobilization depresses insulin signaling in skeletal muscle
Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1235 - E1241.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Hirai, H. Kawano, O. Hirashima, T. Motoyama, Y. Moriyama, T. Sakamoto, K. Kugiyama, H. Ogawa, K. Nakao, and H. Yasue
Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C
Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1172 - H1178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Thorell, J. Nygren, M. F. Hirshman, T. Hayashi, K. S. Nair, E. S. Horton, L. J. Goodyear, and O. Ljungqvist
Surgery-induced insulin resistance in human patients: relation to glucose transport and utilization
Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E754 - E761.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online