AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 275: E294-E299, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paolisso, G.
Right arrow Articles by D'Onofrio, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paolisso, G.
Right arrow Articles by D'Onofrio, F.
Vol. 275, Issue 2, E294-E299, August 1998

Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha

Giuseppe Paolisso1, Maria Rosaria Rizzo1, Gherardo Mazziotti2, Maria Rosaria Tagliamonte1, Antonio Gambardella1, Mario Rotondi2, Carlo Carella2, Dario Giugliano1, Michele Varricchio1, and Felice D'Onofrio1

1 Department of Geriatric Medicine and Metabolic Diseases and 2 Institute of Endocrinology-II, University of Napoli, 80138 Naples, Italy

In 70 healthy subjects with a large age range, the relationships between plasma tumor necrosis factor-alpha (TNF-alpha ) and body composition, insulin action, and substrate oxidation were investigated. In the cross-sectional study (n = 70), advancing age correlated with plasma TNF-alpha concentration (r = 0.64, P < 0.001) and whole body glucose disposal (WBGD; r= -0.38, P < 0.01). The correlation between plasma TNF-alpha and age was independent of sex and body fat (BF; r = 0.31, P < 0.01). Independent of age and sex, a significant relationship between plasma TNF-alpha and leptin concentration (r = 0.29, P < 0.02) was also found. After control for age, sex, BF, and waist-to-hip ratio (WHR), plasma TNF-alpha was still correlated with WBGD (r = -0.33, P < 0.007). Further correction for plasma free fatty acid (FFA) concentration made the latter correlation no more significant. In a multivariate analysis, a model made by age, sex, BF, fat- free mass, WHR, and plasma TNF-alpha concentrations explained 69% of WBGD variability with age (P < 0.009), BF (P < 0.006), fat-free mass (P < 0.005), and plasma TNF-alpha (P < 0.05) significantly and independently associated with WBGD. In the longitudinal study, made with subjects at the highest tertiles of plasma TNF-alpha concentration (n = 50), plasma TNF-alpha concentration predicted a decline in WBGD independent of age, sex, BF, WHR [relative risk (RR) = 2.0; 95% confidence intervals (CI) = 1.2-2.4]. After further adjustment for plasma fasting FFA concentration, the predictive role of fasting plasma TNF-alpha concentration on WBGD (RR = 1.2; CI = 0.8-1.5) was no more significant. In conclusion, our study demonstrates that plasma TNF-alpha concentration is significantly associated with advancing age and that it predicts the impairment in insulin action with advancing age.

insulin action; substrate oxidation


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. M. Peterson, K. D. Feeback, J. H. Baas, and F. X. Pizza
Tumor necrosis factor-{alpha} promotes the accumulation of neutrophils and macrophages in skeletal muscle
J Appl Physiol, November 1, 2006; 101(5): 1394 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. M. W. Petersen and B. K. Pedersen
The anti-inflammatory effect of exercise
J Appl Physiol, April 1, 2005; 98(4): 1154 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. M. Edelberg, A. Wong, J. M. Holm, M. Xaymardan, I. Duignan, A. Chin, J. R. Kizer, and D. Cai
Phage display identification of age-associated TNF{alpha}-mediated cardiac oxidative induction
Physiol Genomics, August 11, 2004; 18(3): 255 - 260.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Cai, M. Xaymardan, J. M. Holm, J. Zheng, J. R. Kizer, and J. M. Edelberg
Age-associated impairment in TNF-{alpha} cardioprotection from myocardial infarction
Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H463 - H469.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
S. Dzienis-Straczkowska, M. Straczkowski, M. Szelachowska, A. Stepien, I. Kowalska, and I. Kinalska
Soluble Tumor Necrosis Factor-{alpha} Receptors in Young Obese Subjects With Normal and Impaired Glucose Tolerance
Diabetes Care, March 1, 2003; 26(3): 875 - 880.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. P. Kirwan, R. K. Krishnan, J. A. Weaver, L. F. Del Aguila, and W. J. Evans
Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia
Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1137 - E1143.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. S. GREIWE, B. CHENG, D. C. RUBIN, K. E. YARASHESKI, and C. F. SEMENKOVICH
Resistance exercise decreases skeletal muscle tumor necrosis factor {alpha} in frail elderly humans
FASEB J, February 1, 2001; 15(2): 475 - 482.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Hirai, H. Kawano, O. Hirashima, T. Motoyama, Y. Moriyama, T. Sakamoto, K. Kugiyama, H. Ogawa, K. Nakao, and H. Yasue
Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C
Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1172 - H1178.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online