AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 275: E243-E248, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goichot, B.
Right arrow Articles by Brandenberger, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goichot, B.
Right arrow Articles by Brandenberger, G.
Vol. 275, Issue 2, E243-E248, August 1998

Effect of the shift of the sleep-wake cycle on three robust endocrine markers of the circadian clock

Bernard Goichot, Laurence Weibel, Florian Chapotot, Claude Gronfier, François Piquard, and Gabrielle Brandenberger

Laboratoire des Régulations Physiologiques et des Rythmes Biologiques chez l'Homme, Institut de Physiologie, 67085 Strasbourg Cedex, France

To determine the effect of a phase shift in sleep on the circadian clock, thyroid-stimulating hormone (TSH), cortisol, and melatonin, three robust markers of the circadian clock, were analyzed using a 10-min blood sampling procedure. In an initial experiment eight subjects were studied during two experimental sessions: once under baseline conditions with normal nighttime sleep from 2300 to 0700 (baseline) and once after a night of sleep deprivation followed by daytime sleep from 0700 to 1500 (day 1). In a second experiment, carried out on seven subjects, the 24-h hormone profiles of the first day (day 1) were compared with those of the second day (day 2) of the sleep shift. During the night of sleep deprivation (day 1) the TSH surge was higher than during baseline conditions, whereas melatonin and cortisol rhythms remained unaffected. On day 2 the amplitude of the nocturnal TSH surge was reduced in comparison to day 1, whereas the amplitudes of melatonin and cortisol rhythms were unchanged. There was a clear phase shift in the three endocrine rhythms. Triiodothyronine levels were slightly higher in the morning after the first night of sleep deprivation. These results demonstrate that 2 consecutive days of sleep shift are sufficient to affect the timing of the commonly accepted circadian markers, suggesting the existence of a rapid resetting effect on the circadian clock. TSH reacts in a distinctive manner to the sleep-wake cycle manipulation by modulating the amplitude of the nocturnal surge. This amplitude modulation is probably an integral part of the phase-shifting mechanisms controlled by the circadian clock.

thyroid-stimulating hormone; melatonin; cortisol; circadian rhythms


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Goel
An arousing, musically enhanced bird song stimulus mediates circadian rhythm phase advances in dim light
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R822 - R827.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Goel
Late-night presentation of an auditory stimulus phase delays human circadian rhythms
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R209 - R216.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. C. Antle and R. E. Mistlberger
Circadian Clock Resetting by Sleep Deprivation without Exercise in the Syrian Hamster
J. Neurosci., December 15, 2000; 20(24): 9326 - 9332.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. M. Buxton, M. L'Hermite-Baleriaux, F. W. Turek, and E. van Cauter
Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R373 - R382.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online