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Am J Physiol Endocrinol Metab 275: E6-E11, 1998;
0193-1849/98 $5.00
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Vol. 275, Issue 1, E6-E11, July 1998

Plasma growth hormone secretion is impaired in obesity-prone rats before onset of diet-induced obesity

Thomas J. Lauterio1, Ariel Barkan2, Mark DeAngelo1, Roberta DeMott-Friberg2, and Ray Ramirez3

2 Medical Service, Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48105; and 1 Departments of Physiology and Internal Medicine and 3 Surgery, Eastern Virginia Medical School, Norfolk, Virginia 23501

Sprague-Dawley rats, which become obese (obesity prone) when fed a moderately high-fat (MHF; 32.5% of kcal as fat) diet, have decreased growth hormone (GH) concentrations compared with obesity-resistant rats fed the same diet. To determine whether plasma GH concentrations are different in obesity-prone rats compared with obesity-resistant rats before diet-induced obesity occurs, total integrated GH concentrations were determined in male Sprague-Dawley rats before exposure to the MHF diet. After initial blood sampling, rats were fed an MHF diet for 15 wk, over which time the animals were separated into two discrete populations based on body weight gain. Analysis of GH in episodic blood samples showed that the obesity-prone group had a GH secretion deficit before the onset of obesity (115.2 ± 12.9 ng · ml-1 · 200 min-1) compared with obesity-resistant rats (237.2 ± 47.1 ng · ml-1 · 200 min-1). The GH concentration difference was due to a decrease in mean GH peak height in rats that later became obese (34.8 ng/ml) compared with rats that remained lean (74.2 ng/ml). The results suggest that GH secretion impairment exists before dietary challenge or onset of obesity and may contribute to the susceptibility to obesity observed in these animals.

episodic growth hormone secretion; dietary fat


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