| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Internal Medicine and 2 Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-8887
These studies used the suckling lamb as a model to determine the sources of cholesterol that are utilized for development of the central nervous system in the neonate. Lambs were studied at 1.3 and 16.4 days after birth. Over this 15-day interval, 14 g of new brain tissue were formed. About 9-10 mg of cholesterol were utilized daily for this new tissue growth. To determine the source of this cholesterol, the absolute rates of low-density lipoprotein clearance and cholesterol synthesis were measured in vivo in nine separate regions of the central nervous system. Low-density lipoprotein clearance throughout the brain was very low and at most could have contributed only 0.3-0.4 mg cholesterol daily for new brain growth. In contrast, the brain synthesized 7-8 mg of cholesterol/day. There were pronounced regional differences in the concentration of cholesterol throughout the brain, and these correlated closely with the rate of sterol synthesis (r = 0.95) in these same regions. We conclude that the principal source of sterol for brain growth in suckling lambs is de novo synthesis.
central nervous system; hepatic; cholesteryl ester; low-density lipoprotein; ovine
This article has been cited by other articles:
|
|
 |
|
  B. Karten, D. E. Vance, R. B. Campenot, and J. E. Vance Trafficking of Cholesterol from Cell Bodies to Distal Axons in Niemann Pick C1-deficient Neurons J. Biol. Chem., January 31, 2003; 278(6): 4168 - 4175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Panzenboeck, Z. Balazs, A. Sovic, A. Hrzenjak, S. Levak-Frank, A. Wintersperger, E. Malle, and W. Sattler ABCA1 and Scavenger Receptor Class B, Type I, Are Modulators of Reverse Sterol Transport at an in Vitro Blood-Brain Barrier Constituted of Porcine Brain Capillary Endothelial Cells J. Biol. Chem., November 1, 2002; 277(45): 42781 - 42789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Xie, L. A. Woollett, S. D. Turley, and J. M. Dietschy Fatty acids differentially regulate hepatic cholesteryl ester formation and incorporation into lipoproteins in the liver of the mouse J. Lipid Res., September 1, 2002; 43(9): 1508 - 1519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Meaney, M. Hassan, A. Sakinis, D. Lütjohann, K. von Bergmann, A. Wennmalm, U. Diczfalusy, and I. Björkhem Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study J. Lipid Res., January 1, 2001; 42(1): 70 - 78. [Abstract] [Full Text]
|
|
|
|
|
|
S. Laitinen, V. M. Olkkonen, C. Ehnholm, and E. Ikonen Family of human oxysterol binding protein (OSBP) homologues: a novel member implicated in brain sterol metabolism J. Lipid Res., December 1, 1999; 40(12): 2204 - 2211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Patel, S. Suresh, U. Kumar, C. Y. Hu, A. Cooney, E. J. Blanchette-Mackie, E. B. Neufeld, R. C. Patel, R. O. Brady, Y. C. Patel, et al. Localization of Niemann-Pick C1 protein in astrocytes: Implications for neuronal degeneration in Niemann- Pick type C disease PNAS, February 16, 1999; 96(4): 1657 - 1662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Xie, S. D. Turley, P. G. Pentchev, and J. M. Dietschy Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein Am J Physiol Endocrinol Metab, February 1, 1999; 276(2): E336 - E344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Cruz and T.-Y. Chang Fate of Endogenously Synthesized Cholesterol in Niemann-Pick Type C1 Cells J. Biol. Chem., December 22, 2000; 275(52): 41309 - 41316. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
