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Am J Physiol Endocrinol Metab 274: E1050-E1056, 1998;
0193-1849/98 $5.00
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Vol. 274, Issue 6, E1050-E1056, June 1998

Effect of growth hormone treatment on postprandial protein metabolism in growth hormone-deficient adults

D. L. Russell-Jones1, S. B. Bowes1, S. E. Rees2, N. C. Jackson1, A. J. Weissberger1, R. Hovorka2, P. H. Sonksen1, and A. M. Umpleby1

1 Department of Endocrinology, United Medical and Dental Schools, St. Thomas' Campus, London SE1 7EH; and 2 Department of Systems Science, City University, London EC1V 0HB, United Kingdom

Growth hormone (GH) treatment of GH-deficient adults increases lean body mass. To investigate this anabolic effect of GH, body composition and postabsorptive and postprandial protein metabolism were measured in 12 GH-deficient adults randomized to placebo or GH treatment. Protein metabolism was measured after an infusion of [1-13C]leucine before and after a standard meal at 0 and 2 mo. After 2 mo, there was an increase in lean body mass in the GH group (P < 0.05) but no change in the placebo group. In the postabsorptive state, there was increased nonoxidative leucine disappearance (NOLD; a measure of protein synthesis) and leucine metabolic clearance rate and decreased leucine oxidation in the GH group (P < 0.05) but no change in the placebo group. After the meal, there was an increase in NOLD and oxidation in all studies (P < 0.05), but the increase in NOLD, measured as area under the curve, was greater in the GH group (P < 0.05). This study clearly demonstrates for the first time that the increase in protein synthesis in the postabsorptive state after GH treatment of GH-deficient adults is maintained in the postprandial state.

protein synthesis; stable isotopes; feeding


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