AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 274: E903-E908, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clodi, M.
Right arrow Articles by Ludvik, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clodi, M.
Right arrow Articles by Ludvik, B.
Vol. 274, Issue 5, E903-E908, May 1998

Distribution and kinetics of amylin in humans

M. Clodi1, K. Thomaseth2, G. Pacini2, K. Hermann1, A. Kautzky-Willer1, W. Waldhäusl1, R. Prager1, and B. Ludvik1

1 Division of Endocrinology and Metabolism, Department of Medicine III, University of Vienna, A-1097 Vienna, Austria; and 2 Institute of Systems Science and Biomedical Engineering (LADSEB-Consiglio Nazionale delle Ricerche), 35127 Padua, Italy

The aim of the study was to determine the apparent volume of distribution (VTOT), total body clearance (CL), fractional clearance, and mean residence time (MRT) of the beta -cell hormone amylin. We therefore performed an intravenous injection of 50 µg of human synthetic amylin (amlintide) in nine healthy male subjects during suppression of endogenous amylin release by intravenous somatostatin (0.06 µg · kg-1 · min-1). The plasma levels of amylin concentrations over time were analyzed using three-exponential curves. VTOT was 173 ± 16 ml/kg and was not different from that of insulin reported in the literature (157 ml/kg). MRT was 27.7 ± 2.1 min and thus two times the reported value for insulin (14.1 min) and C-peptide (16.4 min). CL and fractional CL were 6.2 ± 0.2 ml · kg-1 · min-1 and 0.038 ± 0.003 min-1, respectively. Fractional CL is therefore definitely lower than that reported for insulin (0.12-0.2 min-1) but is, however, in the range of that of C-peptide (0.05 min-1). In conclusion, clearance of amylin is similar to that reported for C-peptide and much slower than insulin, indicating that the commonly used molar insulin-to-amylin ratio does not reflect the correct relationship of the two peptides.

pharmakokinetics; noncompartmental analysis; compartmental analysis; mathematical modeling


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Tura, G. Pacini, A. Kautzky-Willer, B. Ludvik, R. Prager, and K. Thomaseth
Basal and dynamic proinsulin-insulin relationship to assess {beta}-cell function during OGTT in metabolic disorders
Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E155 - E162.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. B. Juhl, N. Porksen, J. Sturis, A. P. Hansen, J. D. Veldhuis, S. Pincus, M. Fineman, and O. Schmitz
High-frequency oscillations in circulating amylin concentrations in healthy humans
Am J Physiol Endocrinol Metab, March 1, 2000; 278(3): E484 - E490.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online