AJP - Endo AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 274: E779-E784, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moreno-Reyes, R.
Right arrow Articles by Copinschi, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moreno-Reyes, R.
Right arrow Articles by Copinschi, G.
Vol. 274, Issue 5, E779-E784, May 1998

Evidence against a role for the growth hormone-releasing peptide axis in human slow-wave sleep regulation

Rodrigo Moreno-Reyes1, Myriam Kerkhofs2, Mireille L'Hermite-Balériaux1, Michael O. Thorner3, Eve Van Cauter4, and Georges Copinschi1

1 Center for the Study of Biological Rhythms (CERB), Department of Endocrinology and Laboratory of Experimental Medicine, and 2 Sleep Laboratory, Department of Psychiatry, Hôpital Erasme, Université Libre de Bruxelles, B-1070 Brussels, Belgium; 3 Department of Medicine, University of Virginia, Charlottesville, Virginia 22908; and 4 Department of Medicine, University of Chicago, Chicago, Illinois 60637

A complex interrelationship exists between sleep and somatotropic activity. In humans, intravenous injections of growth hormone-releasing hormone (GHRH) given during sleep consistently stimulate slow-wave (SW) sleep, particularly when given in the latter part of the night. In the present study, the possible somnogenic effects induced under similar conditions by GH-releasing peptide (GHRP) were investigated in seven young healthy men. Bolus intravenous injections of GHRP-2 (1 µg/kg body wt) or saline, in randomized order, were given after 60 s of the third rapid-eye-movement period. All GHRP injections were immediately followed by transient prolactin elevations and by GH pulses of a magnitude within or around the upper limit of the physiological range. Except for a nonsignificant tendency to increased amounts of wakefulness during the 1st h after the injection, no effects of GHRP-2 administration on sleep were detected. There was in particular no enhancement of SW sleep. Thus, in contrast to GHRH, late-night single injections of GHRP-2 at a dosage resulting in similar GH elevations have no stimulatory effects on SW sleep. The present data provide evidence against the involvement of the GHRP axis in human SW sleep regulation.

prolactin; rapid-eye-movement sleep


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. Szentirmai, L. Kapas, Y. Sun, R. G. Smith, and J. M. Krueger
Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R510 - R517.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. Szentirmai, L. Kapas, and J. M. Krueger
Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R575 - R585.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Bodosi, J. Gardi, I. Hajdu, E. Szentirmai, F. Obal Jr., and J. M. Krueger
Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1071 - R1079.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. C. Weikel, A. Wichniak, M. Ising, H. Brunner, E. Friess, K. Held, S. Mathias, D. A. Schmid, M. Uhr, and A. Steiger
Ghrelin promotes slow-wave sleep in humans
Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E407 - E415.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. Obal Jr., J. Alt, P. Taishi, J. Gardi, and J. M. Krueger
Sleep in mice with nonfunctional growth hormone-releasing hormone receptors
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R131 - R139.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online