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1 Departments of Medicine,
This study tested
the hypothesis that increasing the protein content of isocaloric meals
increases the rate of myofibrillar synthesis in muscle of healthy
subjects over 60 yr old and enhances the stimulation of myofibrillar
synthesis induced by resistance exercise. Myofibrillar synthesis of
sedentary and exercised quadriceps muscle was determined by
incorporation of
L-[1-13C]leucine.
During the tracer infusion, subjects consumed meals with a low (7% of
energy, n = 6)-, normal (14%,
n = 6)-, or high (28%,
n = 6)-protein content. In sedentary
muscle, the mean (± SE) myofibrillar synthesis was 1.56 ± 0.13%/day in the low-protein group, 1.73 ± 0.11 %/day in the
normal-protein group, and 1.76 ± 0.10%/day in the high-protein
group (P = 0.42). Myofibrillar synthesis was faster in exercised muscle (mean 27%,
P < 10
6) in all groups (2.10 ± 0.14 %/day in low protein; 2.18 ± 0.10 %/day in normal
protein; 2.11 ± 0.09 %/day in high protein;
P = 0.84). The stimulation of
myofibrillar synthesis by exercise was not significantly different
among low-protein [0.54 ± 0.12 %/day (37 ± 9%)],
normal-protein [0.46 ± 0.08 %/day (28 ± 5%)], and
high-protein groups [0.34 ± 0.04 %/day (20 ± 3%);
P = 0.31]. We conclude that
high-protein meals do not enhance the stimulation of myofibrillar
protein synthesis induced by resistance exercise.
muscle protein synthesis; amino acid concentrations; nutrition
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