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Am J Physiol Endocrinol Metab 274: E493-E501, 1998;
0193-1849/98 $5.00
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Vol. 274, Issue 3, E493-E501, March 1998

Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytes

F. Bradley Hillgartner and Tina Charron

Department of Biochemistry, School of Medicine, West Virginia University, Morgantown, West Virginia 26506

Transcription of fatty acid synthase (FAS) and malic enzyme (ME) in avian liver is low during starvation or feeding a low-carbohydrate, high-fat diet and high during feeding a high-carbohydrate, low-fat diet. The role of glucose in the nutritional control of FAS and ME was investigated by determining the effects of this metabolic fuel on expression of FAS and ME in primary cultures of chick embryo hepatocytes. In the presence of triiodothyronine, glucose (25 mM) stimulated an increase in the activity and mRNA abundance of FAS and ME. These effects required the phosphorylation of glucose to glucose 6-phosphate but not further metabolism downstream of the aldolase step of the glycolytic pathway. Xylitol mimicked the effects of glucose on FAS and ME expression, suggesting that an intermediate of the pentose phosphate pathway may be involved in mediating this response. The effects of glucose on the mRNA abundance of FAS and ME were accompanied by similar changes in transcription of FAS and ME. These data support the hypothesis that glucose plays a role in mediating the effects of nutritional manipulation on transcription of FAS and ME in liver.

fatty acid synthesis; nutritional regulation; glucose signal; liver; thyroid hormone


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