AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 274: E410-E416, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sohlström, A.
Right arrow Articles by Owens, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sohlström, A.
Right arrow Articles by Owens, J. A.
Vol. 274, Issue 3, E410-E416, March 1998

Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig

A. Sohlström1, A. Katsman2, K. L. Kind1, C. T. Roberts1, P. C. Owens1, J. S. Robinson1, and J. A. Owens2

Departments of 1 Obstetrics and Gynaecology and 2 Physiology, University of Adelaide, South Australia 5005, Australia

The effect of moderate food restriction on pregnancy-associated changes in weight gain, body composition, and circulating insulin-like growth factors (IGF) I and II and IGF-binding proteins (IGFBP)-1 through -4 and their relationship was determined in the guinea pig. Pregnancy did not stimulate weight gain but reduced fat deposition in ad libitum-fed animals and increased weight gain and fat deposition in food-restricted animals relative to their respective virginal group. Pregnancy increased the abundance of circulating IGF-I regardless of food intake and increased that of IGF-II in food-restricted animals only. Pregnancy also increased circulating IGFBP-1 and -2 in ad libitum-fed and food-restricted animals and IGFBP-4 in ad libitum-fed animals. Multiple regression analysis showed that maternal weight gain was negatively associated with circulating IGF-II and IGFBP-2. Fetal weight was positively associated with maternal circulating IGF-II and negatively associated with maternal circulating IGFBP-1 and -2. Significant interactions indicate, however, that the role of IGF-II and IGFBP-1 on fetal growth is dependent on the nutritional status of the mother.

insulin-like growth factors; insulin-like growth factor-binding proteins


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. N. Sferruzzi-Perri, J. A. Owens, P. Standen, R. L. Taylor, G. K. Heinemann, J. S. Robinson, and C. T. Roberts
Early treatment of the pregnant guinea pig with IGFs promotes placental transport and nutrient partitioning near term
Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E668 - E676.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. L. Kind, C. T. Roberts, A. I. Sohlstrom, A. Katsman, P. M. Clifton, J. S. Robinson, and J. A. Owens
Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R119 - R126.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. L. Kind, P. M. Clifton, P. A. Grant, P. C. Owens, A. Sohlstrom, C. T. Roberts, J. S. Robinson, and J. A. Owens
Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R140 - R152.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. L. Kind, P. M. Clifton, A. I. Katsman, M. Tsiounis, J. S. Robinson, and J. A. Owens
Restricted fetal growth and the response to dietary cholesterol in the guinea pig
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1999; 277(6): R1675 - R1682.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online