AJP - Endo Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 274: E403-E409, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dengel, D. R.
Right arrow Articles by Supiano, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dengel, D. R.
Right arrow Articles by Supiano, M. A.
Vol. 274, Issue 3, E403-E409, March 1998

Insulin sensitivity is associated with blood pressure response to sodium in older hypertensives

Donald R. Dengel, Robert V. Hogikyan, Michael D. Brown, Scott G. Glickman, and Mark A. Supiano

Division of Geriatric Medicine, Department of Internal Medicine, and the Geriatric Research, Education and Clinical Center, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan 48105

The purpose of this study was to determine whether sodium-resistant hypertensives are more insulin resistant and whether dietary sodium restriction improves insulin sensitivity in older hypertensives. Insulin sensitivity was assessed by a frequently sampled intravenous glucose tolerance test to determine the insulin sensitivity index (SI) after 1 wk each of low- (20 mmol · l-1 · day-1) and high- (200 mmol · l-1 · day-1) sodium diets in 21 older (63 ± 2 yr) hypertensives. Subjects were grouped on the difference in mean arterial blood pressure (MABP) between diets [sodium sensitive (SS): >= 5-mmHg increase in MABP on the high-sodium diet (n = 14); sodium resistant (SR): <5-mmHg increase in MABP on the high-sodium diet (n = 7)]. There was no dietary sodium effect on fasting plasma insulin or SI. An analysis of variance indicated a significant (P = 0.0002) group effect, with SS individuals having lower fasting plasma insulins on the low- (13 ± 2 vs. 27 ± 3 µU/ml) and high- (12 ± 2 vs. 22 ± 3 µU/ml) sodium diets compared with SR individuals. Similarly, there was a significant (P = 0.0002) group effect in regard to SI, with SS individuals having significantly higher SI on the low- (3.26 ± 0.60 vs. 0.91 ± 0.31 µU × 10-4 · min-1 · ml-1) and high- (3.45 ± 0.51 vs. 1.01 ± 0.30 µU × 10-4 · min-1 · ml-1) sodium diets compared with SR individuals. We conclude that SR individuals exhibit a greater degree of insulin resistance than SS individuals and that dietary sodium restriction fails to improve insulin sensitivity regardless of sodium sensitivity status.

aging


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Mate, A. Barfull, A. M. Hermosa, L. Gomez-Amores, C. M. Vazquez, and J. M. Planas
Regulation of sodium-glucose cotransporter SGLT1 in the intestine of hypertensive rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R760 - R767.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. D. Brown, D. R. Dengel, R. V. Hogikyan, and M. A. Supiano
Sympathetic activity and the heterogenous blood pressure response to exercise training in hypertensives
J Appl Physiol, April 1, 2002; 92(4): 1434 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
J. C. ter Maaten, S. J. L. Bakker, E. H. Serne, P. M. ter Wee, A. J. M. Donker, and R. O. B. Gans
Insulin's acute effects on glomerular filtration rate correlate with insulin sensitivity whereas insulin's acute effects on proximal tubular sodium reabsorption correlate with salt sensitivity in normal subjects
Nephrol. Dial. Transplant., October 1, 1999; 14(10): 2357 - 2363.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online