AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 274: E271-E279, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xu, B.
Right arrow Articles by LaNoue, K. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, B.
Right arrow Articles by LaNoue, K. F.
Vol. 274, Issue 2, E271-E279, February 1998

A1 adenosine receptor antagonism improves glucose tolerance in Zucker rats

Baiyang Xu, Deborah A. Berkich, George H. Crist, and Kathryn F. LaNoue

Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033-0850

The A1 adenosine receptor (A1ar) antagonist 1,3-dipropyl-8-(p-acrylic)phenylxanthine (BW-1433) was administered to lean and obese Zucker rats to probe the influence of endogenously activated A1ars on whole body energy metabolism. The drug induced a transient increase in lipolysis as indicated by a rise in serum glycerol in obese rats. The disappearance of the response by day 7 of chronic studies was accompanied by an increase in A1ar numbers. Glucose tolerance tests were administered to rats treated with BW-1433. Peak serum insulin levels and areas under glucose curves (AUGs) were 34 and 41% lower in treated obese animals than in controls, respectively, and 19 and 39% lower in lean animals. With chronic administration (6 wk), AUGs decreased 47 and 33% in obese and lean animals, respectively. There was no effect of BW-1433 in either lean or obese rats on weight gain or percent body fat. Thus the major sustained influence of whole body A1ar antagonism in both lean and obese animals was an increase in whole body glucose tolerance at lower levels of insulin.

obesity; lipolysis; insulin sensitivity


This article has been cited by other articles:


Home page
 FASEB J.Home page
G. FRUHBECK, J. GOMEZ-AMBROSI, and J. SALVADOR
Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes
FASEB J, February 1, 2001; 15(2): 333 - 340.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
G. H. Crist, B. Xu, K. F. Lanoue, and C. H. Lang
Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats
FASEB J, October 1, 1998; 12(13): 1301 - 1308.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online