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Am J Physiol Endocrinol Metab 274: E253-E256, 1998;
0193-1849/98 $5.00
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Vol. 274, Issue 2, E253-E256, February 1998

Synthetic flavonoids cross the placenta in the rat and are found in fetal brain

J. P. Schröder-Van Der Elst1, D. Van Der Heide1, H. Rokos2, G. Morreale De Escobar3, and J. Köhrle4

1 Human and Animal Physiology, Agricultural University, 6709PJ Wageningen, The Netherlands; 2 Henning Berlin, D-13353 Berlin, Germany; 3 Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas, 28029 Madrid, Spain; 4 Klinische Forschergruppe, Medizinische Poliklinik, Universität Würzburg, 8700 Würzburg, Germany

The synthetic flavonoid EMD-49209 is a potent inhibitor of the in vivo and in vitro binding of thyroxine (T4) to transthyretin (TTR). We studied the distribution of 125I-labeled EMD-49209 in maternal tissues, intestinal contents, and fetal tissues in rats that were 20 days pregnant (from 1 to 24 h after intravenous injection). The percent dose of EMD decreased quickly with time. In maternal brain no radioactive flavonoid could be detected. EMD was excreted very rapidly from the intestines. In the fetal compartment the percent dose of EMD increased with time; after 24 h it contained 17% of the EMD. The flavonoid was found in all fetal tissues investigated and also in the fetal brain. Because TTR concentrations are high in the fetal rat, especially in the brain, the transfer of flavonoid to the fetal brain might be linked to TTR expression. The presence of flavonoid in the fetal brain raises the possibility of an essential interference of flavonoids with the availablity of T4 in the fetal compartment.

thyroid hormones; goitrogen


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