AJP - Endo Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 274: E246-E252, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lu, C.-C.
Right arrow Articles by Wang, P. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lu, C.-C.
Right arrow Articles by Wang, P. S.
Vol. 274, Issue 2, E246-E252, February 1998

Effects of ovarian steroid hormones and thyroxine on calcitonin secretion in pregnant rats

Chien-Chen Lu1, Shiow-Chwen Tsai1, Shyi-Wu Wang2, Ching-Lin Tsai3, Chin-Pang Lau1, Hsi-Chang Shih1, Yen-Hao Chen1, Yu-Chung Chiao1, Charlie Liaw1, and Paulus S. Wang1

1 Department of Physiology, School of Life Science, National Yang-Ming University, and 3 Department of Orthopaedic Surgery, School of Medicine, National Taiwan University, Taipei, and 2 Department of Physiology, Chang-Gung University, Tao-Yuan, Taiwan, Republic of China

In the present study, the roles of ovarian steroid hormones and thyroxine (T4) in regulating the secretion of calcitonin (CT) in pregnant rats were examined. The levels of plasma progesterone, pre- and post-CaCl2 plasma CT, and recovery time of plasma CT and calcium after calcium challenge were greatest in midterm pregnant rats. The levels of basal plasma progesterone, CT, calcium, and recovery time of plasma CT after calcium challenge were less in late pregnant rats, but basal plasma estradiol was highest in late pregnancy. The concentrations of plasma T4 were gradually decreased in rats during pregnancy. Regardless of the presence of estradiol, administration of progesterone in ovariectomized (Ovx) rats resulted in an increase of plasma T4 as well as the basal and calcium-induced secretion of CT. Administration of estradiol alone did not alter the CaCl2-induced levels but decreased the post-CaCl2 levels of plasma calcium in Ovx rats. The basal levels of plasma CT were decreased in Ovx rats treated with T4. These results suggest that the hypercalcitoninemia in midterm pregnant rats is due to an increased secretion of progesterone. Hypocalcitoninemia in late pregnant rats, however, is due in part to lower plasma calcium.

estradiol; progesterone


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C.-L. Lu, J.-C. Hsieh, M.-L. Tsaur, Y.-H. Huang, P. S. Wang, L.-L. Wu, P.-Y. Liu, F.-Y. Chang, and S.-D. Lee
Estrogen rapidly modulates mustard oil-induced visceral hypersensitivity in conscious female rats: a role of CREB phosphorylation in spinal dorsal horn neurons
Am J Physiol Gastrointest Liver Physiol, January 1, 2007; 292(1): G438 - G446.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C.-C. Lu, S.-C. Tsai, S.-W. Wang, W. J. S. Huang, and P. S. Wang
Age-related differences in the secretion of calcitonin in female rats
Am J Physiol Endocrinol Metab, November 1, 1998; 275(5): E735 - E739.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online