| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark
Glucose utilization during exercise of a given submaximal power output is decreased after endurance training. The aim of the present study was to elucidate the mechanisms behind this phenomenon by utilizing the sarcolemmal giant vesicle technique. Eight healthy young untrained men endurance trained one thigh for 3 wk. They then exercised both thighs simultaneously at the same work load (77% of peak O2 uptake of the untrained thigh) for 40 min. Training increased muscle GLUT-4 protein by 70% (P < 0.05). Glucose uptake during exercise was 38% lower (P < 0.05) in the trained (T) thigh than in the untrained (UT) thigh because of both a lower (P < 0.05) glucose extraction and blood flow in T. During exercise, sarcolemmal GLUT-4 protein content and glucose transport capacity increased significantly less in T than in UT muscle, and muscle glucose concentration was lower in T compared with UT (P < 0.05) at the end of exercise. It is concluded that, despite a large increase in muscle GLUT-4 with endurance training, exercise of a given submaximal power output increases muscle glucose uptake less in T than in UT muscle. It is suggested that the mechanism behind this phenomenon is blunted exercise-induced translocation of GLUT-4 to the sarcolemma, resulting in a blunted increase in sarcolemmal glucose transport in T muscle.
glucose uptake; citrate synthase; training adaptation; skeletal muscle
This article has been cited by other articles:
|
|
 |
|
  K. De Bock, W. Derave, B. O. Eijnde, M. K. Hesselink, E. Koninckx, A. J. Rose, P. Schrauwen, A. Bonen, E. A. Richter, and P. Hespel Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake J Appl Physiol, April 1, 2008; 104(4): 1045 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ploug and J. Vinten COUNTERPOINT: GLUCOSE PHOSPHORYLATION IS NOT A SIGNIFICANT BARRIER TO GLUCOSE UPTAKE BY THE WORKING MUSCLE J Appl Physiol, December 1, 2006; 101(6): 1805 - 1806. [Full Text] [PDF]
|
|
|
|
|
|
REBUTTAL FROM DRS. WASSERMAN AND FUEGER J Appl Physiol, December 1, 2006; 101(6): 1806 - 1807. [Full Text] [PDF]
|
|
|
|
|
|
D. H. Wasserman and P. T. Fueger Last Word: Point:Counterpoint author responds to commentaries on "Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscle" J Appl Physiol, December 1, 2006; 101(6): 1810 - 1810. [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Rose and E. A. Richter Skeletal Muscle Glucose Uptake During Exercise: How is it Regulated? Physiology, August 1, 2005; 20(4): 260 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Frosig, S. B. Jorgensen, D. G. Hardie, E. A. Richter, and J. F. P. Wojtaszewski 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E411 - E417. [Abstract] [Full Text]
|
|
|
|
|
|
D. A. Hood Plasticity in Skeletal, Cardiac, and Smooth Muscle: Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle J Appl Physiol, March 1, 2001; 90(3): 1137 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kristiansen, J. Gade, J. F. P. Wojtaszewski, B. Kiens, and E. A. Richter Glucose uptake is increased in trained vs. untrained muscle during heavy exercise J Appl Physiol, September 1, 2000; 89(3): 1151 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Dubouchaud, G. E. Butterfield, E. E. Wolfel, B. C. Bergman, and G. A. Brooks Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E571 - E579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Hansen, W. Derave, P. Jensen, and E. A. Richter No limiting role for glycogenin in determining maximal attainable glycogen levels in rat skeletal muscle Am J Physiol Endocrinol Metab, March 1, 2000; 278(3): E398 - E404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dela, K. J. Mikines, J. J. Larsen, and H. Galbo Glucose clearance in aged trained skeletal muscle during maximal insulin with superimposed exercise J Appl Physiol, December 1, 1999; 87(6): 2059 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Bergman, E. E. Wolfel, G. E. Butterfield, G. D. Lopaschuk, G. A. Casazza, M. A. Horning, and G. A. Brooks Active muscle and whole body lactate kinetics after endurance training in men J Appl Physiol, November 1, 1999; 87(5): 1684 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Bergman, G. E. Butterfield, E. E. Wolfel, G. D. Lopaschuk, G. A. Casazza, M. A. Horning, and G. A. Brooks Muscle net glucose uptake and glucose kinetics after endurance training in men Am J Physiol Endocrinol Metab, July 1, 1999; 277(1): E81 - E92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Halseth, D. P. Bracy, and D. H. Wasserman Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo Am J Physiol Endocrinol Metab, January 1, 1999; 276(1): E70 - E77. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
