AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 274: E72-E82, 1998;
0193-1849/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weltan, S. M.
Right arrow Articles by Noakes, T. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weltan, S. M.
Right arrow Articles by Noakes, T. D.
Vol. 274, Issue 1, E72-E82, January 1998

Influence of muscle glycogen content on metabolic regulation

Sandra M. Weltan, Andrew N. Bosch, Steven C. Dennis, and Timothy D. Noakes

Department of Physiology, University of Cape Town Medical School, Observatory 7925, South Africa

Euglycemia was maintained in 13 subjects with low muscle glycogen [low glycogen, euglycemic (LGE), n = 8; low glycogen, euglycemic, hyperinsulinemic (LGEI), n = 5] and 6 subjects with normal muscle glycogen (NGE), whereas hyperglycemia was maintained in 8 low muscle glycogen subjects (LGH). All subjects cycled for 145 min at 70% of maximal oxygen uptake during the infusions. Insulin was infused in LGEI at 0.2 mU · kg-1 · min-1. During exercise, respiratory exchange ratio (RER) was lower and norepinephrine higher in LGE than in NGE. In LGEI and LGH, RER at the start of exercise was the same as in LGE but did not decrease as in LGE. Free fatty acids (FFA) were higher and plasma insulin concentrations lower in LGE than NGE, LGEI, or LGH over the first 45 min of exercise. Rate of glucose infusion (Ri) and rate of glucose oxidation (Rox) were higher in LGH and LGEI than in NGE or LGE, and Ri matched Rox in all groups except LGH, in which Ri was greater than Rox. Muscle glycogen disappearance was greater in NGE than LGE, LGEI, or LGH, but the latter three groups did not differ. In conclusion, this study showed that low muscle glycogen content results in a decrease in RER, an increase in FFA, fat oxidation, and norepinephrine both at rest and during exercise, and does not affect Rox when euglycemia is maintained by infusion of glucose alone. Rox was increased only during insulin and hyperglycemia.

hyperglycemia; euglycemia; muscle glycogen; respiratory exchange ratio


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. Q. Zhang, L. L. Ji, D. L. Fogt, and V. S. Fretwell
Effect of exercise duration on postprandial hypertriglyceridemia in men with metabolic syndrome
J Appl Physiol, October 1, 2007; 103(4): 1339 - 1345.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Ishikawa, W. Mizunoya, T. Shibakusa, K. Inoue, and T. Fushiki
Transforming growth factor-beta in the brain regulates fat metabolism during endurance exercise
Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1151 - E1159.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. C. Greenberg, M. J. Jurczak, A. M. Danos, and M. J. Brady
Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways
Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E1 - E8.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. C. Venables, J. Achten, and A. E. Jeukendrup
Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study
J Appl Physiol, January 1, 2005; 98(1): 160 - 167.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Arkinstall, C. R. Bruce, S. A. Clark, C. A. Rickards, L. M. Burke, and J. A. Hawley
Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity
J Appl Physiol, December 1, 2004; 97(6): 2275 - 2283.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. W. Zderic, S. Schenk, C. J. Davidson, L. O. Byerley, and E. F. Coyle
Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by {beta}-adrenergic blockade
Am J Physiol Endocrinol Metab, December 1, 2004; 287(6): E1195 - E1201.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. A. Johnson, S. R. Stannard, K. Mehalski, M. I. Trenell, T. Sachinwalla, C. H. Thompson, and M. W. Thompson
Intramyocellular triacylglycerol in prolonged cycling with high- and low-carbohydrate availability
J Appl Physiol, April 1, 2003; 94(4): 1365 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Arkinstall, C. R. Bruce, V. Nikolopoulos, A. P. Garnham, and J. A. Hawley
Effect of carbohydrate ingestion on metabolism during running and cycling
J Appl Physiol, November 1, 2001; 91(5): 2125 - 2134.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. W. Zderic, A. R. Coggan, and B. C. Ruby
Glucose kinetics and substrate oxidation during exercise in the follicular and luteal phases
J Appl Physiol, February 1, 2001; 90(2): 447 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. H. Goedecke, A. S. C. Gibson, L. Grobler, M. Collins, T. D. Noakes, and E. V. Lambert
Determinants of the variability in respiratory exchange ratio at rest and during exercise in trained athletes
Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1325 - E1334.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. Malkova, R. D. Evans, K. N. Frayn, S. M. Humphreys, P. R. M. Jones, and A. E. Hardman
Prior exercise and postprandial substrate extraction across the human leg
Am J Physiol Endocrinol Metab, November 1, 2000; 279(5): E1020 - E1028.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. C. Riddell, O. Bar-Or, M. Hollidge-Horvat, H. P. Schwarcz, and G. J. F. Heigenhauser
Glucose ingestion and substrate utilization during exercise in boys with IDDM
J Appl Physiol, April 1, 2000; 88(4): 1239 - 1246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. M. Gill and A. E Hardman
Postprandial lipemia: effects of exercise and restriction of energy intake compared1
Am. J. Clinical Nutrition, February 1, 2000; 71(2): 465 - 471.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Casey, R. Mann, K. Banister, J. Fox, P. G. Morris, I. A. Macdonald, and P. L. Greenhaff
Effect of carbohydrate ingestion on glycogen resynthesis in human liver and skeletal muscle, measured by 13C MRS
Am J Physiol Endocrinol Metab, January 1, 2000; 278(1): E65 - E75.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. B. McClelland, P. W. Hochachka, and J.-M. Weber
Carbohydrate utilization during exercise after high-altitude acclimation: A new perspective
PNAS, August 18, 1998; 95(17): 10288 - 10293.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. M. Weltan, A. N. Bosch, S. C. Dennis, and T. D. Noakes
Preexercise muscle glycogen content affects metabolism during exercise despite maintenance of hyperglycemia
Am J Physiol Endocrinol Metab, January 1, 1998; 274(1): E83 - E88.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online