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Am J Physiol Endocrinol Metab 274: E52-E56, 1998;
0193-1849/98 $5.00
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Vol. 274, Issue 1, E52-E56, January 1998

Differential effects of rat pregnancy on uterine and lung atrial natriuretic factor receptors

Patrice Vaillancourt, Saeed Omer, Xing-Fei Deng, Shree Mulay, and Daya R. Varma

Departments of Physiology, Medicine, and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6

We investigated if the refractoriness to the tocolytic effects of atrial natriuretic factor (ANF) during rat pregnancy is due to a downregulation of one or both guanylyl cyclase (GC)-coupled GC-A and GC-B ANF receptors; lungs were used as controls. Uteri and lungs of virgin, pregnant (days 7, 16, and 21), and day 2 postpartum rats expressed mRNAs for GC-A and GC-B as well as GC-uncoupled ANF-C receptors. GC-B receptor protein was more abundant than GC-A in uteri; the reverse was the case in lungs. Pregnancy decreased uterine mRNAs and proteins for GC-A and GC-B receptors as well as the effects of ANF and C-type natriuretic peptide (CNP) on uterine GC activity; lung ANF receptors and effects of ANF and CNP on lung GC activity were not modulated by pregnancy. It is concluded that pregnancy induces organ-specific modulation of ANF receptors and a downregulation of ANF-GC receptors would minimize interference with uterine motility during pregnancy.

atrial natriuretic factor receptor mRNA; atrial natriuretic factor receptor protein; guanosine 3',5'-cyclic monophosphate; C-type natriuretic peptide; postpartum


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