AJP - Endo Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 273: E903-E907, 1997;
0193-1849/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meyer, C.
Right arrow Articles by Gerich, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meyer, C.
Right arrow Articles by Gerich, J.
Vol. 273, Issue 5, E903-E907, November 1997

Role of the kidney in human leptin metabolism

Christian Meyer1, Dave Robson1, Noya Rackovsky1, Veena Nadkarni1, and John Gerich1,2

Departments of 1 Medicine and 2 Physiology and Pharmacology, University of Rochester School of Medicine, Rochester, New York 14642

To assess the role of the human kidney in leptin metabolism, we measured renal leptin net balance and urinary leptin excretion in 16 normal postabsorptive volunteers with varying degrees of obesity. Arterial leptin concentrations (11.6 ± 2.7 ng/ml) significantly exceeded renal vein concentrations (10.3 ± 2.5 ng/ml, P < 0.001). Renal leptin fractional extraction averaged 13.1 ± 1.1%, and renal leptin net balance (uptake) averaged 1,070 ± 253 ng/min. Lineweaver-Burk analysis indicated that renal leptin uptake followed saturation kinetics with an apparent Michaelis-Menten constant of 10.9 ng/ml and maximal velocity of 1,730 ng/min. Leptin was generally undetectable in urine. Using literature values for systemic leptin clearance, we calculated that renal leptin uptake could account for ~80% of all leptin removal from plasma. These data indicate that the human kidney plays a substantial role in leptin removal from plasma by taking up and degrading the peptide.

obesity


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
G. Coatmellec-Taglioni, J.-P. Dausse, Y. Giudicelli, and C. Ribiere
Sexual Dimorphism in Cafeteria Diet-Induced Hypertension Is Associated with Gender-Related Difference in Renal Leptin Receptor Down-Regulation
J. Pharmacol. Exp. Ther., April 1, 2003; 305(1): 362 - 367.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. J. Fogteloo, A. E. Meinders, H. Pijl, A. A. Kroon, M. Frolich, and P. W. De Leeuw
Renal clearance of endogenous leptin in hypertensive humans with or without renal artery stenosis
Am J Physiol Endocrinol Metab, August 1, 2001; 281(2): E400 - E404.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. D Jensen, N. Moller, K Sreekumaran Nair, P. Eisenberg, M. Landt, and S. Klein
Regional leptin kinetics in humans
Am. J. Clinical Nutrition, January 1, 1999; 69(1): 18 - 21.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online