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The Human Performance Laboratory, Department of Kinesiology and Health Education and Division of Nutritional Sciences, The University of Texas at Austin, Austin, Texas 78712
This study determined if the suppression of
lipolysis after preexercise carbohydrate ingestion reduces fat
oxidation during exercise. Six healthy, active men cycled 60 min at 44 ± 2% peak oxygen consumption, exactly 1 h after ingesting 0.8 g/kg
of glucose (Glc) or fructose (Fru) or after an overnight fast (Fast).
The mean plasma insulin concentration during the 50 min before exercise was different among Fast, Fru, and Glc (8 ± 1, 17 ± 1, and 38 ± 5 µU/ml, respectively; P < 0.05). After 25 min of exercise, whole body lipolysis was 6.9 ± 0.2, 4.3 ± 0.3, and 3.2 ± 0.5 µmol · kg
1 · min1
and fat oxidation was 6.1 ± 0.2, 4.2 ± 0.5, and 3.1 ± 0.3 µmol · kg1 · min1
during Fast, Fru, and Glc, respectively (all
P < 0.05). During Fast, fat
oxidation was less than lipolysis
(P < 0.05), whereas fat oxidation
approximately equaled lipolysis during Fru and Glc. In an additional
trial, the same subjects ingested glucose (0.8 g/kg) 1 h before
exercise and lipolysis was simultaneously increased by infusing
Intralipid and heparin throughout the resting and exercise periods
(Glc+Lipid). This elevation of lipolysis during Glc+Lipid increased fat
oxidation 30% above Glc (4.0 ± 0.4 vs. 3.1 ± 0.3 µmol · kg1 · min1;
P < 0.05), confirming that lipolysis
limited fat oxidation. In summary, small elevations in plasma insulin
before exercise suppressed lipolysis during exercise to the point at
which it equaled and appeared to limit fat oxidation.
insulin; preexercise meal; glycemic index; stable isotopes
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