| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Gifford Laboratories,
Obesity is associated with both insulin
resistance and hyperinsulinemia. Initially hyperinsulinemia compensates
for the insulin resistance and thereby maintains normal glucose
homeostasis. Obesity is also associated with increased tissue
triglyceride (TG) content. To determine whether both insulin resistance
and hyperinsulinemia might be secondary to increased tissue TG, we
studied correlations between TG content of skeletal muscle, liver, and
pancreas and plasma insulin, plasma [insulin] × [glucose], and 
-cell function in four rat models with
widely varying fat content: obese Zucker diabetic fatty rats,
free-feeding lean Wistar rats, hyperleptinemic Wistar rats with
profound tissue lipopenia, and rats pair fed to hyperleptinemics.
Correlation coefficients >0.9 (P < 0.05) were obtained among TG of skeletal muscle, liver, and pancreas and among plasma insulin, [insulin] × [glucose] product, and -cell function as gauged by
basal, glucose-stimulated, and arginine-stimulated insulin secretion by
the isolated perfused pancreas. Although these correlations cannot
prove cause and effect, they are consistent with the hypothesis that
the TG content of tissues sets the level of both insulin resistance and
insulin production.
tissue fat; obese Zucker diabetic fatty rats; -cell
function
This article has been cited by other articles:
|
|
 |
|
  Y. Tian, R. F. Corkey, G. C. Yaney, P. B. Goforth, L. S. Satin, and L. Moitoso de Vargas Differential modulation of L-type calcium channel subunits by oleate Am J Physiol Endocrinol Metab, June 1, 2008; 294(6): E1178 - E1186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. Bobulescu, M. Dubree, J. Zhang, P. McLeroy, and O. W. Moe Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1315 - F1322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sebastian, L. Herrero, D. Serra, G. Asins, and F. G. Hegardt CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E677 - E686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Park, Y.-R. Cho, H.-J. Kim, E.-G. Hong, T. Higashimori, S. J. Lee, I. J. Goldberg, G. I. Shulman, S. M. Najjar, and J. K. Kim Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1 Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E517 - E524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. C. van Loon Use of intramuscular triacylglycerol as a substrate source during exercise in humans J Appl Physiol, October 1, 2004; 97(4): 1170 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. C. van Loon, R. Koopman, R. Manders, W. van der Weegen, G. P. van Kranenburg, and H. A. Keizer Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E558 - E565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. O'Keefe, F. R. Perez, J. A. Sloniger, M. E. Tischler, and E. J. Henriksen Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscle J Appl Physiol, July 1, 2004; 97(1): 63 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Faraj and K. Cianflone Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP Am J Physiol Endocrinol Metab, July 1, 2004; 287(1): E150 - E159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Henriksen, M. K. Teachey, Z. C. Taylor, S. Jacob, A. Ptock, K. Kramer, and O. Hasselwander Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E98 - E105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Clerk, M. E. Smith, S. Rattigan, and M. G. Clark Nonnutritive flow impairs uptake of fatty acid by white muscles of the perfused rat hindlimb Am J Physiol Endocrinol Metab, March 1, 2003; 284(3): E611 - E617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Sniderman, T. Scantlebury, and K. Cianflone Hypertriglyceridemic HyperapoB: The Unappreciated Atherogenic Dyslipoproteinemia in Type 2 Diabetes Mellitus Ann Intern Med, September 18, 2001; 135(6): 447 - 459. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
