| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Endocrinology and Metabolism, Vol 273, Issue 3 E584-E592, Copyright © 1997 by American Physiological Society
ARTICLES |
E. Hagstrom-Toft, S. Enoksson, E. Moberg, J. Bolinder and P. Arner
Department of Medicine, Huddinge University Hospital, Karolinska Institute, Sweden.
The absolute concentrations of glycerol and lactate were studied with microdialysis of adipose tissue and skeletal muscle in normal-weight subjects. The basal interstitial glycerol concentration was 232 +/- 33, 96 +/- 8, and 59 +/- 6 mumol/l in fat, muscle, and arterialized plasma, respectively (P = 0.0002). This relationship was maintained during both euglycemic hyperinsulinemia, when glycerol decreased in all three compartments, and hypoglycemia, when glycerol first decreased and then increased in fat, muscle, and blood (P = 0.0001 for both). Basal interstitial lactate concentrations were similar in adipose tissue (1.1 +/- 0.2 mmol/l) and skeletal muscle (1.9 +/- 0.4 mmol/l) and higher than in arterialized blood (0.6 +/- 0.1 mmol/l, P = 0.002). During hyperinsulinemia and hypoglycemia, lactate increased (P = 0.0001) and the tissue-blood relationship was maintained (P = 0.04). In conclusion, adipose tissue and skeletal muscle mobilize glycerol and lactate at rest. Glycerol and lactate production are influenced by hyperinsulinemia and hypoglycemia in both tissues. Adipose tissue appears to be the major site of glycerol production, whereas skeletal muscle and fat may be equally important for lactate production.
This article has been cited by other articles:
|
|
 |
|
  V. Qvisth, E. Hagstrom-Toft, E. Moberg, S. Sjoberg, and J. Bolinder Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E709 - E714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Burgess, F. M. H. Jeffrey, C. Storey, A. Milde, N. Hausler, M. E. Merritt, H. Mulder, C. Holm, A. D. Sherry, and C. R. Malloy Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting Am J Physiol Endocrinol Metab, July 1, 2005; 289(1): E53 - E61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Djurhuus, C. H. Gravholt, S. Nielsen, S. B. Pedersen, N. Moller, and O. Schmitz Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E488 - E494. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Hagstrom-Toft, V. Qvisth, I. Nennesmo, M. Ryden, H. Bolinder, S. Enoksson, J. Bolinder, and P. Arner Marked Heterogeneity of Human Skeletal Muscle Lipolysis at Rest Diabetes, December 1, 2002; 51(12): 3376 - 3383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Moberg, S. Sjoberg, E. Hagstrom-Toft, and J. Bolinder No apparent suppression by insulin of in vivo skeletal muscle lipolysis in nonobese women Am J Physiol Endocrinol Metab, August 1, 2002; 283(2): E295 - E301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Djurhuus, C. H. Gravholt, S. Nielsen, A. Mengel, J. S. Christiansen, O. E. Schmitz, and N. Moller Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E172 - E177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hamrin, H. Rosdahl, U. Ungerstedt, and J. Henriksson Microdialysis in human skeletal muscle: effects of adding a colloid to the perfusate J Appl Physiol, January 1, 2002; 92(1): 385 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Ettinger, C. C. Poellmann, N. A. Wisniewski, A. A. Gaskin, J. S. Shoemaker, J. M. Poulson, M. W. Dewhirst, and B. Klitzman Urea as a Recovery Marker for Quantitative Assessment of Tumor Interstitial Solutes with Microdialysis Cancer Res., November 1, 2001; 61(21): 7964 - 7970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hagstrom-Toft, A. Thorne, S. Reynisdottir, E. Moberg, S. Rossner, J. Bolinder, and P. Arner Evidence for a Major Role of Skeletal Muscle Lipolysis in the Regulation of Lipid Oxidation During Caloric Restriction In Vivo Diabetes, July 1, 2001; 50(7): 1604 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F Horowitz, S. W Coppack, and S. Klein Whole-body and adipose tissue glucose metabolism in response to short-term fasting in lean and obese women Am. J. Clinical Nutrition, March 1, 2001; 73(3): 517 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Novel-Chate, V. Rey, R. Chiolero, P. Schneiter, X. Leverve, E. Jequier, and L. Tappy Role of Na+-K+-ATPase in insulin-induced lactate release by skeletal muscle Am J Physiol Endocrinol Metab, February 1, 2001; 280(2): E296 - E300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chien, D. Dean, A. K. Saha, J. P. Flatt, and N. B. Ruderman Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo Am J Physiol Endocrinol Metab, August 1, 2000; 279(2): E259 - E265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Stallknecht, J. J. Larsen, K. J. Mikines, L. Simonsen, J. Bulow, and H. Galbo Effect of training on insulin sensitivity of glucose uptake and lipolysis in human adipose tissue Am J Physiol Endocrinol Metab, August 1, 2000; 279(2): E376 - E385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Gravholt, O. Schmitz, L. Simonsen, J. Bulow, J. S. Christiansen, and N. Moller Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue Am J Physiol Endocrinol Metab, November 1, 1999; 277(5): E848 - E854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. MacLean, J. Bangsbo, and B. Saltin Muscle interstitial glucose and lactate levels during dynamic exercise in humans determined by microdialysis J Appl Physiol, October 1, 1999; 87(4): 1483 - 1490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Schaupp, M. Ellmerer, G. A. Brunner, A. Wutte, G. Sendlhofer, Z. Trajanoski, F. Skrabal, T. R. Pieber, and P. Wach Direct access to interstitial fluid in adipose tissue in humans by use of open-flow microperfusion Am J Physiol Endocrinol Metab, February 1, 1999; 276(2): E401 - E408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kamel, S. Norgren, B. Persson, and C. Marcus Insulin induced hypoglycaemia: comparison of glucose and glycerol concentrations in plasma and microdialysate from subcutaneous adipose tissue Arch. Dis. Child., January 1, 1999; 80(1): 42 - 45. [Abstract] [Full Text]
|
|
|
|
|
|
E. Hagstrom-Toft, S. Enoksson, E. Moberg, J. Bolinder, and P. Arner beta -Adrenergic regulation of lipolysis and blood flow in human skeletal muscle in vivo Am J Physiol Endocrinol Metab, December 1, 1998; 275(6): E909 - E916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kiens and E. A. Richter Utilization of skeletal muscle triacylglycerol during postexercise recovery in humans Am J Physiol Endocrinol Metab, August 1, 1998; 275(2): E332 - E337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Rosdahl, K. Hamrin, U. Ungerstedt, and J. Henriksson Metabolite levels in human skeletal muscle and adipose tissue studied with microdialysis at low perfusion flow Am J Physiol Endocrinol Metab, May 1, 1998; 274(5): E936 - E945. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
