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Am J Physiol Endocrinol Metab 273: E262-E267, 1997;
0193-1849/97 $5.00
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AJP - Endocrinology and Metabolism, Vol 273, Issue 2 E262-E267, Copyright © 1997 by American Physiological Society

ARTICLES

Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphatase and liver glycogen levels

S. Metzger, N. Goldschmidt, V. Barash, T. Peretz, O. Drize, J. Shilyansky, E. Shiloni and T. Chajek-Shaul
Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.

Mice bearing interleukin-6 (IL-6)-secreting tumor were used to study the chronic effect of IL-6 on carbohydrate metabolism. Mice were injected with allogeneic tumor cells transduced with the murine IL-6 gene. Serum IL-6 levels were correlated exponentially with tumor weight. Secretion of IL-6 from the developed tumors was associated with decreased food consumption, reduced body weight, and reduced blood glucose levels. Insulin levels did not change, and 2-deoxyglucose uptake was not affected in most tissues examined. A significant increase of 2-deoxyglucose uptake was measured in the liver. Glycogen content in the liver determined 0, 6, 12, and 18 days after tumor inoculation was 42, 23, 12, and 3 mg/g, respectively. The activity of phosphoenolpyruvate carboxykinase was not affected. The activity of glucose-6-phosphatase (G-6-Phase) determined 6, 12, and 18 days after tumor injection was 84, 70, and 50% of G-6-Pase activity in pair-fed mice bearing nonsecreting tumors, respectively. G-6-Pase mRNA levels were markedly reduced due to inhibition of G-6-Pase gene transcriptional rate.


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